{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:32:41Z","timestamp":1788384761926,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the metacarpophalangeal pattern profile (MCPP) of healthy children and adolescents from S\u00e3o Paulo, Brazil, and to establish percentile curves by chronological age (CA), bone age (BA), and sex using the LMS method. Additionally, to compare these findings with previous population\u2010based data and to apply the derived standards to patients with skeletal dysplasias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Left hand and wrist radiographs were obtained from healthy individuals and age\u2010matched patients with confirmed skeletal dysplasias. Tubular bone lengths were compared across CA and BA, against prior normative studies, and with dysplastic cohorts using Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test. Patient Z\u2010scores were calculated from LMS parameters generated from the healthy population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 974 radiographs from healthy subjects and 83 from patients (18 hypochondroplasia, 27 achondroplasia, 14 osteogenesis imperfecta, 24 Turner syndrome). In healthy participants, hand bone lengths correlated significantly with CA and BA. Compared with international reference data, differences in mean metacarpal and phalangeal lengths were noted. Patients with achondroplasia and hypochondroplasia exhibited markedly reduced Z\u2010scores relative to controls, whereas those with Turner syndrome showed reductions of up to 1.8 SD in the fourth metacarpal. Patients with osteogenesis imperfecta demonstrated no significant deviations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study established MCPP reference percentiles for Brazilian children and adolescents using the LMS method. Bone measurements showed consistent associations with CA and BA. Although differences were observed relative to international cohorts, the generated standards effectively discriminated dysplastic phenotypes, particularly achondroplasia and hypochondroplasia, supporting the use of MCPP analysis as an adjunct tool for evaluating short stature and suspected skeletal dysplasias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.70212","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:33:42Z","timestamp":1770024822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Metacarpophalangeal Pattern Profile: An Old Method With New Insights Into the Evaluation of Short Stature"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-5037","authenticated-orcid":false,"given":"Marcelo Damaso","family":"Maruichi","sequence":"first","affiliation":[{"name":"Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5255-2060","authenticated-orcid":false,"given":"Bruno Telma","family":"Destailleur","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1948-2492","authenticated-orcid":false,"given":"Giulia Maesta","family":"Apelbaum","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6361-5235","authenticated-orcid":false,"given":"Carlos Alberto","family":"Longui","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2727-8646","authenticated-orcid":false,"given":"Cristiane","family":"Kochi","sequence":"additional","affiliation":[{"name":"Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.154.5.2108539"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.1.37"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201019\u201010\u20101312"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010019\u201004435\u2010z"},{"key":"e_1_2_11_6_1","volume-title":"GeneReviews","author":"Bober M. 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