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First, secular trend in age at menarche were assessed using time\u2010series models across 5\u2010year birth cohorts for the overall population. Then, 5\u2010year birth cohorts were combined into two groups based on the data availability for the determinant analyses: an earlier\u2010born group (1941\u20131975), whose age at menarche was reported retrospectively in adulthood, and a later\u2010born group (1991\u20132005), whose age at menarche was collected during childhood and\/or adolescence. Bayesian linear regression models were fitted for each group, adjusting for 5\u2010year birth cohort and continent of birth in all models, and additionally for educational level in the earlier\u2010born group and body mass index (BMI) in the later\u2010born group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age at menarche decreased by 1.9\u2009years, from 13.1 to 11.1, between the 1931\u20131935 and 2006\u20132008 birth cohorts, with a steeper decline after 1975. Compared with European\u2010born participants, those born in South\/Central America (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      [95% CI]: 0.33 [0.30, 0.36] years) and Africa (0.52 [0.45, 0.58] years) experienced later menarche in the earlier\u2010born group, whereas those born in South\/Central America experienced earlier menarche in the later\u2010born group (\u22120.18 [\u22120.28, \u22120.09] years). In the later\u2010born group, lower BMI was associated with later menarche (0.96 [0.74, 1.18] years) whereas higher BMI with earlier onset (\u22120.53 [\u22120.57, \u22120.48] years).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a marked decline in age at menarche in the Valencian Community. Factors associated with age at menarche included continent of birth (with cohort\u2010specific effects) and BMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.70322","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:18:21Z","timestamp":1788329901000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secular Trend in Age at Menarche and Associated Determinants in the Valencian Population (Spain)"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6560-601X","authenticated-orcid":false,"given":"Andrea","family":"Beneito","sequence":"first","affiliation":[{"name":"Catalan Institute of Health\u2013Camp de Tarragona Primary Care Center Montblanc  Montblanc Spain"},{"name":"Epidemiology and Environmental Health Joint Research Unit FISABIO\u2013Universitat Jaume I\u2013Universitat de Val\u00e8ncia  Valencia 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