{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:55:33Z","timestamp":1790754933931,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03HD062715"],"award-info":[{"award-number":["R03HD062715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Hum Biol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The intrauterine environment exerts lasting impacts on fetal growth and development, with potential long\u2010term effects on later health. We examined whether placental DNA methylation at\n                      <jats:italic>HSD11B2<\/jats:italic>\n                      and\n                      <jats:italic>IGF2<\/jats:italic>\n                      \u2014two key regulators of the intrauterine environment\u2014is associated with fetal growth among participants in the Cebu Longitudinal Health and Nutrition Survey (CLHNS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed DNA methylation in placental samples from 19 births in the CLHNS using the Illumina Infinium HumanMethylation450 BeadChip. Focusing on CpG sites within\n                      <jats:italic>HSD11B2<\/jats:italic>\n                      and the\n                      <jats:italic>IGF2\/H19<\/jats:italic>\n                      imprinting control region (ICR), we used linear regression models adjusted for gestational age to assess associations of DNA methylation with birth weight, head circumference, length, and neonatal adiposity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher methylation at three CpG sites within\n                      <jats:italic>HSD11B2<\/jats:italic>\n                      was significantly associated with reduced fetal growth: one site was associated with reduced birth weight and head circumference, and two sites were associated with shorter birth length. Within the\n                      <jats:italic>IGF2\/H19<\/jats:italic>\n                      ICR, two CpG sites were significantly associated with both increased birth weight and head circumference. Both CpGs overlapped with predicted CCCTC\u2010binding factor (CTCF) binding sites, consistent with known regulatory mechanisms linking increased methylation at the ICR to increased\n                      <jats:italic>IGF2<\/jats:italic>\n                      expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      These findings support the hypothesis that DNA methylation at regulatory regions of\n                      <jats:italic>HSD11B2<\/jats:italic>\n                      and\n                      <jats:italic>IGF2<\/jats:italic>\n                      contributes to variation in fetal growth, linking placental epigenetic patterns to birth outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajhb.70336","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:56:07Z","timestamp":1790751367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placental\n                    <scp>DNA<\/scp>\n                    Methylation of\n                    <scp>\n                      <i>HSD11B2<\/i>\n                    <\/scp>\n                    and\n                    <scp>\n                      <i>IGF2<\/i>\n                    <\/scp>\n                    Is Associated With Fetal Growth in the Cebu Longitudinal Health and Nutrition Survey"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1473-5123","authenticated-orcid":false,"given":"Eleanor","family":"Klibaner\u2010Schiff","sequence":"first","affiliation":[{"name":"Department of Human Evolutionary Biology Harvard University  Cambridge Massachusetts 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