{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:23:34Z","timestamp":1790778214021,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,2,19]],"date-time":"2003-02-19T00:00:00Z","timestamp":1045612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"US Environmental Protection Agency, Washington, D.C.","award":["82653501"],"award-info":[{"award-number":["82653501"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft, Bonn","doi-asserted-by":"crossref","award":["Br 1825\/3-1"],"award-info":[{"award-number":["Br 1825\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>German studies of high exposure prevalence have been debated on the renal carcinogenicity of trichloroethylene (TRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A consecutive hospital\u2010based case\u2010control study with 134 renal cell cancer (RCC) cases and 401 controls was conducted to reevaluate the risk of TRI in this region which were estimated in a previous study. Exposure was self\u2010assessed to compare these studies. Additionally, the job history was analyzed, using expert\u2010based exposure information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The logistic regression results, adjusted for age, gender, and smoking, confirmed a TRI\u2010related RCC risk in this region. Using the database CAREX for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI\u2010exposing industries (odds ratio (OR) 1.80, 95% confidence interval (CI) 1.01\u20133.20). Any exposure in \u201cmetal degreasing\u201d was a RCC risk factor (OR 5.57, 95% CI 2.33\u201313.32). Self\u2010reported narcotic symptoms, indicative of peak exposures, were associated with an excess risk (OR 3.71, 95% CI 1.80\u20137.54).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The study supports the human nephrocarcinogenicity of trichloroethylene. Am. J. Ind. Med. 43:274\u2013285, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.10185","type":"journal-article","created":{"date-parts":[[2003,2,20]],"date-time":"2003-02-20T14:01:07Z","timestamp":1045749667000},"page":"274-285","source":"Crossref","is-referenced-by-count":89,"title":["Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case\u2010control study in Arnsberg, Germany"],"prefix":"10.1002","volume":"43","author":[{"given":"Thomas","family":"Br\u00fcning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"Pesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Wiesenh\u00fctter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Rabstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marga","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Baum\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann M.","family":"Bolt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,2,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199507000-00008"},{"key":"e_1_2_1_3_1","first-page":"556","article-title":"Updated and expanded Swedish cohort study on trichloroethylene and cancer risk","volume":"36","author":"Axelson O","year":"1994","journal-title":"J Occup Med"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009667"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/104732201456168"},{"key":"e_1_2_1_6_1","first-page":"235","article-title":"[Job exposure matrices]","volume":"42","author":"Bouyer J","year":"1994","journal-title":"Rev Epidemiol Sante Publique"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440091159202"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004320000206"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004320050260"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(90)90110-9"},{"key":"e_1_2_1_11_1","volume-title":"Toxikologisch\u2010arbeitsmedizinische Begr\u00fcndungen von MAK\u2010Werten","author":"DFG","year":"1996"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199907)36:1<54::AID-AJIM8>3.0.CO;2-0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008959"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx00043a001"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004320050298"},{"key":"e_1_2_1_16_1","volume-title":"[Multicenter Urothelial and Renal Cancer Study] Multizentrische Nieren\u2010 und Urothel\u2010Carcinom\u2010Studie (Abschlu\u00dfbericht). 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