{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T19:36:49Z","timestamp":1767382609529},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,3,16]],"date-time":"2001-03-16T00:00:00Z","timestamp":984700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>1,5\u2010naphthalene\u2010diisocyanate (NDI) is an aromatic diisocyanate with a very low vapor pressure which is mainly used in the automotive industry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study we described five cases with workplace\u2010related asthma and one case with extrinsic allergic alveolitis associated with pulmonary hemorrhage after NDI exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Corresponding to case histories, extrinsic alveolitis on asthmatic reactions in three subjects and a rhinitis reaction in one patient could be reproduced by inhalative challenge tests to NDI at a concentration of 10 ppb. Preliminary IgE and IgG antibody analyses in patients' sera did not produce significantly positive results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>According to the outcome of our tests and in comparison with several other studies, we conclude that NDI should be classified as potent airway\u2010sensitizing substance. Improved workplace conditions and decrease in threshold limit values should therefore be recommended. <jats:italic>Am. J. Ind. Med.<\/jats:italic> 39:369\u2013372, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.1027","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T09:42:46Z","timestamp":1098956566000},"page":"369-372","source":"Crossref","is-referenced-by-count":14,"title":["Respiratory diseases caused by occupational exposure to 1,5\u2010naphthalene\u2010diisocyanate (NDI): Results of workplace\u2010related challenge tests and antibody analyses"],"prefix":"10.1002","volume":"39","author":[{"given":"X.","family":"Baur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Marczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,3,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1986.9937414"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00380772"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199802)33:2<114::AID-AJIM3>3.0.CO;2-Y"},{"key":"e_1_2_1_6_1","first-page":"129","article-title":"Enzyme\u2010linked immunosorbent assay, ELISA 3. Quantification of specific antibodies by enzyme\u2010labeled anti\u2010immunoglobulin in antigen\u2010coated tubes","volume":"109","author":"Engvall E","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1995.9935964"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.34.6.762"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(92)90267-N"},{"key":"e_1_2_1_10_1","first-page":"5","article-title":"Lung volumes and forced ventilatory flows. Report of the working party standardization of lung function tests. European Community for Steel and Coal","volume":"6","author":"Quanjer PH","year":"1993","journal-title":"J Eur Respir J"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70181-2"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.1027","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.1027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T15:29:23Z","timestamp":1700407763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.1027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,16]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["10.1002\/ajim.1027"],"URL":"https:\/\/doi.org\/10.1002\/ajim.1027","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,16]]}}}