{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:49:14Z","timestamp":1790941754370,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,10,15]],"date-time":"2003-10-15T00:00:00Z","timestamp":1066176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A medical surveillance program of benzene\u2010exposed workers has to be established in such a way as to observe early signs of benzene\u2010induced cytopenia, pancytopenia, or leukemia. This study evaluates the utility of routine medical survey applied to benzene\u2010exposed workers by analyzing the hematological, immunological, and cytogenetic assay results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The results of a previous study of hematological, immunological, and cytogenetic assays in benzene\u2010exposed workers (up to 15 ppm) are used to discuss medical surveillance program by defining the relationship between various benzene exposure concentrations and toxic endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Exposure to benzene concentration lower than 5 ppm does not produce any abnormal hematological measurements. For benzene cumulative exposure above 100 (ppm\u2010years), some blood indices [mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), band neutrophils] show significant differences in comparison to the control group. The incidence of dicentric chromosomes was higher and the level of B\u2010lymphocytes was lower even with workers exposed to 5 ppm of benzene; correlation with exposure indicators was not found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results suggest that peripheral blood indices, although not sensitive enough, are still the most suitable parameters in a health surveillance program applied to benzene\u2010exposed workers. B\u2010lymphocytes could be a promising indicator of the benzene\u2010induced damage. Cytogenetic tests did not prove to be suitable. Further investigation of useful screening tests for health surveillance program of benzene\u2010exposed workers is still required. Am. J. Ind. Med. 44:467\u2013473, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.10296","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T12:02:20Z","timestamp":1066392140000},"page":"467-473","source":"Crossref","is-referenced-by-count":12,"title":["Utility of a routine medical surveillance program with benzene exposed workers"],"prefix":"10.1002","volume":"44","author":[{"given":"Ana","family":"Bogadi\u2010\u0160are","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marija","family":"Zavali\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajka","family":"Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,10,15]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"296","article-title":"Haematological effects of chronic benzene poisoning in 217 workers","volume":"28","author":"Aksoy M","year":"1971","journal-title":"Brit J Ind Med"},{"key":"e_1_2_1_3_1","first-page":"56","article-title":"Details of blood changes in 32 patients with pancytopenia associated with long\u2010term exposure to benzene","volume":"29","author":"Aksoy M","year":"1972","journal-title":"Brit J Ind Med"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90390-X"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.35.367"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/074823379701300402"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004200000126"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(98)00045-X"},{"key":"e_1_2_1_9_1","first-page":"619","article-title":"A study of the hematologic effects of chronic low\u2010level exposure to benzene","volume":"33","author":"Collins JJ","year":"1991","journal-title":"J Occ Med"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199703000-00013"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199107000-00015"},{"key":"e_1_2_1_12_1","first-page":"249","article-title":"Clinical accuracy of updated version of Phadebas\u00ae Test","volume":"46","author":"De Fillippi I","year":"1981","journal-title":"Ann Allergy"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00984100050166352"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-197808000-00005"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198610000-00028"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10090"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1984.10545874"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.1078"},{"key":"e_1_2_1_19_1","first-page":"443","article-title":"Lymphocyte subpopulations in peripheral blood of healthy persons. Characterisation by surface markers and lack of selection during purification","volume":"20","author":"Holm G","year":"1975","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_20_1","unstructured":"IAEA.1986.International Atomic Energy Agency. Biological dosimetry. Chromosomal aberration analysis for dose assessment.Vienna; IAEA TRS No 260."},{"key":"e_1_2_1_21_1","first-page":"93","volume-title":"Some industrial chemicals and dyestuffs. Monographs on the evaluation of the carcinogenic risk of chemicals to humans","author":"IARC","year":"1982"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-199909000-00015"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8982199"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(02)00010-4"},{"key":"e_1_2_1_25_1","first-page":"1109","volume-title":"Environmental and occupational medicine","author":"Landrigan PJ","year":"1998"},{"key":"e_1_2_1_26_1","volume-title":"Carcinogenicity and toxicity of benzene","author":"Mehlman MA","year":"1983"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700200514"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/13.1.57"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10121"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199603)29:3<236::AID-AJIM3>3.0.CO;2-O"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00984100050166334"},{"key":"e_1_2_1_32_1","first-page":"273","volume-title":"Encyclopaedia of occupational health and safety","author":"Stellman JM","year":"1998"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00167-4"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)90207-0"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198309000-00018"},{"key":"e_1_2_1_36_1","unstructured":"WHO.1993.Benzene. Environmental health criteria 150.Geneva: World Health Organization 145p."},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(81)90325-2"},{"key":"e_1_2_1_38_1","first-page":"694","article-title":"Genotoxic effects in peripheral blood and urine of workers exposed to low level benzene","volume":"45","author":"Yardley\u2010Jones A","year":"1988","journal-title":"Brit J Ind Med"},{"key":"e_1_2_1_39_1","first-page":"48","article-title":"Analysis of chromosomal aberrations in workers exposed to low level benzene","volume":"47","author":"Yardley\u2010Jones A","year":"1990","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_40_1","first-page":"437","article-title":"The toxicity of benzene and its metabolism and molecular pathology in human risk assessment","volume":"48","author":"Yardley\u2010Jones A","year":"1991","journal-title":"Brit J Ind Med"},{"key":"e_1_2_1_41_1","first-page":"399","article-title":"The effects of occupational exposure to hydrocarbons on some immune parameters of workers of Phenol Division of a petrochemical plant","volume":"3","author":"Zeman K","year":"1990","journal-title":"Pol J Occup Med"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/20024091064165"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.10296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.10296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T01:57:06Z","timestamp":1700272626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.10296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,15]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1002\/ajim.10296"],"URL":"https:\/\/doi.org\/10.1002\/ajim.10296","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,15]]}}}