{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:40:34Z","timestamp":1761986434642},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,3,16]],"date-time":"2009-03-16T00:00:00Z","timestamp":1237161600000},"content-version":"vor","delay-in-days":2906,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hemp dust exposure is associated with byssinosis and accelerated lung loss in longitudinal studies. The immunological changes associated with hemp dust exposure are less well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied a small group of current male hemp processors with a mean age of 43 years. Questionnaire data, lung function, serial FEV<jats:sub>1<\/jats:sub> and blood were collected from all workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, seven workers (64%) complained of at least one respiratory symptom (one with byssinosis). The mean percentage predicted FEV<jats:sub>1<\/jats:sub> was 91.5, FVC 97.7, PEF 92.1, and FEF<jats:sub>25\u201375<\/jats:sub> 79.5. Serial FEV<jats:sub>1<\/jats:sub> measurements in the two workers with work\u2010related respiratory symptoms revealed a mean change in FEV<jats:sub>1<\/jats:sub> on the first working day of \u221212.9%. This contrasted with +6.25% on the last working day. Respective values for the two workers without work\u2010related symptoms were \u22121.4 and +3.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lung function changes and abnormalities in a profile of cell surface activation markers and antibodies were noted to relate to the presence of work\u2010related respiratory symptoms, not seen in the control group. <jats:italic>Am. J. Ind. Med.<\/jats:italic> 39:419\u2013425, 2001. 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