{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:48:39Z","timestamp":1777110519046,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,19]],"date-time":"2004-07-19T00:00:00Z","timestamp":1090195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several case\u2010control studies have found an association between chronic beryllium disease (CBD) and <jats:italic>HLA\u2010DPB1<\/jats:italic> gene variants. However, the relationship between <jats:italic>HLA\u2010DPB1<\/jats:italic> and beryllium sensitization, and whether the presence of one or two <jats:italic>HLA\u2010DPB1<jats:sup>Glu69<\/jats:sup><\/jats:italic> alleles is differentially associated with CBD and beryllium sensitization have not been completely resolved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Restriction fragment length polymorphism (RFLP) analysis was used to address these questions in a large population\u2010based cohort consisting of 884 beryllium workers (90 with CBD, 64 beryllium sensitized).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>HLA\u2010DPB1<jats:sup>Glu69<\/jats:sup><\/jats:italic> was associated with both CBD (OR\u2009=\u20099.4; 95% CI\u2009=\u20095.4, 16.6) and sensitization (OR\u2009=\u20093.3, 95% CI\u2009=\u20091.9, 5.9). Further, workers with CBD and sensitization were more likely to be homozygous <jats:italic>HLA\u2010DPB1<jats:sup>Glu69<\/jats:sup><\/jats:italic> compared to workers without disease or sensitization (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Follow\u2010up of this cohort, scrutiny of <jats:italic>HLA\u2010DPB1<\/jats:italic> haplotypes, and evaluation of gene\u2013environment and gene\u2013gene interactions will be important for fully understanding the immunogenetic nature of this occupational disease. Am. J. Ind. Med. 46:95\u2013103, 2004. 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