{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:00:34Z","timestamp":1697612434838},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T00:00:00Z","timestamp":1142812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Swine containment facilities are often highly contaminated with organic dusts that often contain varying levels of endotoxins and other microbial products. This study was performed to evaluate the effect of obesity on the inflammatory response induced by chronic or acute exposure to swine confinement buildings (SCB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two separate studies were performed; Study I included 36 SCB long\u2010time workers and a control group of 35 matched male hospital workers never exposed to SCB. In Study II, 14 na\u00efve healthy young subjects (8 overweight and 6 lean) volunteered to be acutely exposed to a SCB environment for 5 hr. Markers of sub\u2010clinical inflammation linked to obesity (C\u2010reactive protein (CRP), interleukin 6 (IL\u20106)) or to active inflammation (soluble adhesion molecules, IL\u20108, TNF) were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first study, positive correlations were found between girth circumference and serum levels of IL\u20106 (r\u2009=\u20090.57, <jats:italic>P<\/jats:italic>\u2009=\u20090.0003) and CRP (r\u2009=\u20090.62, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) in the control group. These correlations were however blunted or lost in the SCB workers group who showed positive correlations between girth circumference and soluble <jats:sc>l<\/jats:sc>\u2010selectin (r\u2009=\u20090.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.04), TNF\u03b1 (r\u2009=\u20090.37, <jats:italic>P<\/jats:italic>\u2009=\u20090.03), ICAM\u20101 (r\u2009=\u20090.61, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><jats:p>In the second study involving acute SCB exposure of na\u00efve volunteers, no significant differences were observed between normal weight and overweight subjects for white blood cells, nasal lavage cell counts, and IL\u20108 levels. However, higher levels of CRP, TNF, and IL\u20106 were detected in overweight volunteers compared to those who were lean.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In pig farmers (Study I), environmentally induced chronic inflammation appears to blunt the sub\u2010clinical inflammation linked to obesity, whereas in na\u00efve volunteers of Study II, environmentally induced acute inflammation seems to have a potentiating effect on obesity\u2010related inflammatory markers. Am. J. Ind. Med. 49:281\u2013285, 2006. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.20265","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T22:50:07Z","timestamp":1142895007000},"page":"281-285","source":"Crossref","is-referenced-by-count":3,"title":["Adiposity affects human response to inhaled organic dust"],"prefix":"10.1002","volume":"49","author":[{"given":"Yvon","family":"Cormier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Isra\u00ebl\u2010Assayag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(89)90060-9"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700270104"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/15298668391405265"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15298669091369709"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10071516"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802495"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/00028899908984426"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10162"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.60.6.444"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7678183"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.4.7921472"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-0542(04)90013-9"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.16.1519"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1183\/09031936.96.09030524","article-title":"Pig farmers have signs of bronchial inflammation and increased numbers of lymphocytes and neutrophils in BAL fluid","volume":"9","author":"Pedersen B","year":"1996","journal-title":"Eur Respir J"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.248.9.1073"},{"issue":"1","key":"e_1_2_1_17_1","first-page":"S9","article-title":"Inflammation, atherosclerosis, and cardiovascular risk: An epidemiologic view","volume":"10","author":"Ridker PM","year":"1999","journal-title":"Blood Coagl Fibrinolysis"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000055014.62083.05"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90173-6"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.54.7.466"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9703087"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90349-3"},{"key":"e_1_2_1_23_1","first-page":"II","article-title":"Inflammation as a Cardiovascular Risk Factor","volume":"109","author":"Willerson JT","year":"2004","journal-title":"Circulation"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00463-3"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.20265","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.20265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T05:29:34Z","timestamp":1697606974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.20265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,20]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1002\/ajim.20265"],"URL":"https:\/\/doi.org\/10.1002\/ajim.20265","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,20]]}}}