{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:40:38Z","timestamp":1790941238608,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A variety of neurophysiological measures are useful in hospital settings for diagnostic and other clinical purposes. Previously, abnormal changes in various sensory evoked potentials (EPs), and heart rate variability (HRV) were observed in patients with acquired and fetal Minamata disease (MD; methylmercury poisoning). In recent years, some of these methods have been used for the risk assessment of low\u2010level methylmercury exposure in asymptomatic children. The objectives of this article were to present an overview of neurophysiological findings involved in methylmercury neurotoxicity and to examine the usefulness of those measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The reports addressing both neurophysiological measures and methylmercury exposure in humans were identified and evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The neurological signs and symptoms of MD included paresthesias, constriction of visual fields, impairment of hearing and speech, mental disturbances, excessive sweating, and hypersalivation. Neuropathological lesions involved visual, auditory, and post\u2010 and pre\u2010central cortex areas. Neurophysiological changes involved in methylmercury, as assessed by EPs and HRV, were found to be in accordance with both clinical and neuropathological observations in patients with MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EPs and HRV appear to be useful and objective methods for assessing methylmercury neurotoxicity. However, subtle changes due to low\u2010level methylmercury exposure may not necessarily be of clinical relevance, and interpretation of small deviations from expectations must be cautious. Am. J. Ind. Med. 50:765\u2013771, 2007. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.20471","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T15:36:22Z","timestamp":1177083382000},"page":"765-771","source":"Crossref","is-referenced-by-count":36,"title":["Neurophysiological evidence of methylmercury neurotoxicity"],"prefix":"10.1002","volume":"50","author":[{"given":"Katsuyuki","family":"Murata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Grandjean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwako","family":"Dakeishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1997.3822"},{"key":"e_1_2_1_3_1","first-page":"710","article-title":"Application of neurophysiological methods in occupational medicine in relation to psychological performance","volume":"23","author":"Araki S","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1997.3708"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(200002)37:2<193::AID-AJIM5>3.0.CO;2-J"},{"key":"e_1_2_1_6_1","first-page":"229","article-title":"Evoked potentials in the assessment of neurotoxicity in humans","volume":"7","author":"Arezzo JC","year":"1985","journal-title":"Neurobehav Toxicol Teratol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880110713"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.56.651.1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01217-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00283-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0272-4332.2004.00560.x"},{"key":"e_1_2_1_12_1","volume-title":"Evoked potentials in clinical medicine","author":"Chiappa KH","year":"1997"},{"key":"e_1_2_1_13_1","first-page":"341","volume-title":"Evoked potentials in clinical medicine","author":"Chiappa KH","year":"1997"},{"key":"e_1_2_1_14_1","unstructured":"Committee on Environmental and Natural Resources Office of Science and Technology Policy and the White House.1999.Report of the Workshop on \u201cScientific Issues Relevant to Assessment of Health Effects from Exposure to Methylmercury\u201d. 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