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This study identifies the costs, characteristics, and contributing factors associated with livestock\u2010handling injuries among Colorado dairy farmers, cattle\/livestock raisers, and cattle dealers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 10\u2010year (1997\u20132006) history of Colorado's workers' compensation claims data was used for analysis. Descriptive analyses of livestock\u2010handling injury claims were performed. Claim cost analysis was also conducted. The agent\u2013host\u2013environment epidemiological model was used to analyze injury event descriptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1,114 livestock\u2010handling claims were analyzed. Claims associated with milking parlor tasks represented nearly 50% of injuries among dairy workers. Claims associated with riding horseback, sorting\/penning cattle, and livestock\u2010handling equipment represented high proportions of livestock\u2010handling injuries among cattle\/livestock raisers and cattle dealers. Claims associated with livestock\u2010handling represented the highest percentage of high\u2010cost and high\u2010severity injuries in all three sectors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Livestock\u2010handling injuries are a significant problem, more costly, and result in more time off work than other causes of agricultural injuries. There is a strong and compelling need to develop cost\u2010effective interventions to reduce the number of livestock\u2010handling injuries in agriculture. Am. J. Ind. 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