{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:28:43Z","timestamp":1774124923002,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T00:00:00Z","timestamp":1250121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Workplace surveillance identifies chronic beryllium disease (CBD) but it remains unknown over what time frame mild CBD will progress to a more severe form.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined physiology and treatment in 229 beryllium sensitization (BeS) and 171 CBD surveillance\u2010identified cases diagnosed from 1982 to 2002. Never smoking CBD cases (81) were compared to never smoking BeS patients (83) to assess disease progression. We compared CBD machinists to non\u2010machinists to examine effects of exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, CBD and BeS cases did not differ significantly in exposure time or physiology. CBD patients were more likely to have machined beryllium. Of CBD cases, 19.3% went on to require oral immunosuppressive therapy. At 30 years from first exposure, measures of gas exchange were significantly worse and total lung capacity was lower for CBD subjects. Machinists had faster disease progression as measured by pulmonary function testing and gas exchange.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Medical surveillance for CBD identifies individuals at significant risk of disease progression and impairment with sufficient time since first exposure. Am. J. Ind. Med. 52:762\u2013773, 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.20736","type":"journal-article","created":{"date-parts":[[2009,8,13]],"date-time":"2009-08-13T12:59:10Z","timestamp":1250168350000},"page":"762-773","source":"Crossref","is-referenced-by-count":31,"title":["Beryllium lymphocyte proliferation test surveillance identifies clinically significant beryllium disease"],"prefix":"10.1002","volume":"52","author":[{"given":"Margaret M.","family":"Mroz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa A.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Strand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Silviera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee S.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,9,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000232548.03207.9f"},{"key":"e_1_2_1_3_1","first-page":"592","article-title":"Berylliosis in Italy: A case of \u201csarcoidosis\u201d under the threshold limit value","volume":"97","author":"Contini S","year":"2006","journal-title":"Med Lav"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1012616"},{"key":"e_1_2_1_5_1","first-page":"201","article-title":"Chronic beryllium disease in a precious metal refinery: Clinical, epidemiologic, and immunologic evidence for continuing risk from exposure to low level beryllium fume","volume":"135","author":"Cullen MR","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2006.027987"},{"key":"e_1_2_1_7_1","first-page":"567","article-title":"Acute dermatitis and pneumonitis in beryllium workers: Review of 406 cases in eight\u2010year period with follow\u2010up on recoveries","volume":"45","author":"DeNardi JM","year":"1949","journal-title":"Ohio State Med J"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(49)90435-0"},{"key":"e_1_2_1_9_1","first-page":"68854","article-title":"Chronic beryllium disease prevention program","volume":"64","author":"DOE, U.D.O.E","year":"1999","journal-title":"Fed Regist"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198303000-00012"},{"key":"e_1_2_1_11_1","first-page":"144","article-title":"Misdiagnosis of sarcoidosis in patients with chronic beryllium disease","volume":"20","author":"Fireman E","year":"2003","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"e_1_2_1_12_1","first-page":"132","article-title":"Respiratory pathophysiology in chronic beryllium disease: Review of 30 cases with some observations after long term steroid therapy","volume":"19","author":"Gaensler EA","year":"1959","journal-title":"AMA Arch Ind Health"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12260036"},{"key":"e_1_2_1_14_1","first-page":"133","volume-title":"Pneumoconiosis. Sixth Saranac Symposium","author":"Hardy HL","year":"1950"},{"key":"e_1_2_1_15_1","first-page":"174","article-title":"The disability found in persons exposed to certain beryllium compounds","volume":"12","author":"Hardy HL","year":"1955","journal-title":"AMA Arch Ind Health"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196511252732205"},{"key":"e_1_2_1_17_1","first-page":"197","article-title":"Delayed chemical pneumonitis in workers exposed to beryllium compounds","volume":"28","author":"Hardy HL","year":"1946","journal-title":"J Ind Hyg Toxicol"},{"key":"e_1_2_1_18_1","first-page":"271","article-title":"United States Beryllium Case Registry (1952\u20131966)","volume":"9","author":"Hardy H","year":"1966","journal-title":"J Occup Med"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004200100237"},{"key":"e_1_2_1_20_1","volume-title":"Guidelines for the Use of ILO International Classification of Radiographs of Pneumoconioses","author":"International Labor Organization","year":"1980"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.4255"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-198907000-00011"},{"key":"e_1_2_1_23_1","first-page":"267","article-title":"Beryllium disease screening in the ceramics industry. Blood lymphocyte test performance and exposure\u2010disease relations","volume":"35","author":"Kreiss K","year":"1993","journal-title":"J Occup Med"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.4_Pt_1.985"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199607)30:1<16::AID-AJIM3>3.0.CO;2-Q"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.54.8.605"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.5.1702"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.7.2012123"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(91)90300-D"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00112205"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/139.6.1479"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200103000-00011"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-190OC"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.3.661"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.01.019"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1983.10544010"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7845"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-5-687"},{"key":"e_1_2_1_39_1","volume-title":"In SAS State User's Guide, Release 6.03","author":"SAS Institute, Inc","year":"1988"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20140"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.6.2000"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10473220118317"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000184864.10147.bc"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20059"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000233010"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.20736","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.20736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T18:07:26Z","timestamp":1695924446000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.20736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,8]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1002\/ajim.20736"],"URL":"https:\/\/doi.org\/10.1002\/ajim.20736","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,8]]}}}