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This study highlights Scopoli's observations on the interaction between elemental mercury (Hg\u00b0) and alcohol, on the appearance of lung impairment, insomnia, and depressive mood in mercurialism. This presentation is based on Scopoli's experiences presented in his book,<jats:italic>De Hydrargyro Idriensi Tentamina<\/jats:italic>(1761), current knowledge, and our own experience acquired through health monitoring of occupational Hg\u00b0 exposure. Some studies have confirmed Scopoli's observation that alcohol enhances mercurialism and his hypothesis that exposure to high Hg\u00b0 concentrations causes serious lung impairment. Neurobiological studies have highlighted the influence of Hg\u00b0 on sleep disorder and depressive mood observed by Scopoli. Although today's knowledge provides new perspectives of Scopoli's work on mercurialism, his work is still very important and can be considered a part of occupational medicine heritage. Am. J. Ind. Med. 53:535\u2010547, 2010. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajim.20798","type":"journal-article","created":{"date-parts":[[2010,1,28]],"date-time":"2010-01-28T14:15:49Z","timestamp":1264688149000},"page":"535-547","source":"Crossref","is-referenced-by-count":7,"title":["Scopoli's work in the field of mercurialism in light of today's knowledge: Past and present perspectives"],"prefix":"10.1002","volume":"53","author":[{"given":"Alfred Bogomir","family":"Kobal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darja Kobal","family":"Grum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1995.tb00171.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01032.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2007000300001"},{"key":"e_1_2_1_5_1","volume-title":"Toxicological profile for mercury","author":"ATSDR","year":"1999"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008849208686"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8202"},{"key":"e_1_2_1_8_1","unstructured":"\u010carJ.2006.The Skonca beds of the Idrija ore deposit 2. 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