{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:06:31Z","timestamp":1791317191272,"version":"4.3.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T00:00:00Z","timestamp":1287360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Symptoms of obstructive lung disease in domestic cleaning staff have been related to the use of bleach and other irritant cleaning products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>Included in the study were thirteen cleaning employees with work\u2010related asthma\u2010like symptoms, three asthmatic controls and three atopic subjects without bronchial hyperresponsiveness (BHR) who had no exposure to cleaning products. The study protocol consisted of a methacholine test, sputum induction and fraction of exhaled nitric oxide measurement (FENO) both at baseline and 24\u2009hr after a 1\u2010hr inhalation challenge with either placebo or bleach at a concentration of 0.4\u2009ppm of chlorine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The inhalation of the placebo caused no bronchial reactions. Mean maximum fall in FEV<jats:sub>1<\/jats:sub> during challenge testing with bleach was significantly higher than the values obtained during the placebo challenge. Inhalation challenge with bleach elicited two isolated late asthmatic reactions and one dual asthmatic reaction. Of all the patients who underwent challenge testing with bleach, only one had a \u22652\u2010fold decrease in methacholine PC<jats:sub>20<\/jats:sub> 24\u2009hr after the challenge. No significant correlation was found between maximum fall in FEV<jats:sub>1<\/jats:sub> and PC<jats:sub>20<\/jats:sub> methacholine. Following challenge testing with bleach, no clinically significant changes in sputum cell counts or FENO were detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that bleach inhalation at a concentration of 0.4\u2009ppm\u2014a concentration below 8\u2010hr permissible occupational exposure level\u2014brings about a substantial decrease in FEV1 in subjects with and without BHR. Some subjects have a positive challenge response to bleach inhalation. Am. J. Ind. Med. 54:293\u2013299, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.20912","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T18:14:36Z","timestamp":1287425676000},"page":"293-299","source":"Crossref","is-referenced-by-count":52,"title":["Airway response to chlorine inhalation (bleach) among cleaning workers with and without bronchial hyperresponsiveness"],"prefix":"10.1002","volume":"54","author":[{"given":"Joaqu\u00edn","family":"Sastre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro F.","family":"Madero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Fern\u00e1ndez\u2010Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Garc\u00eda\u2010del","family":"Potro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Quirce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.109.2.331"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0103"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00201002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.017640"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00085405"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000058347.05741.f9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.332129"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.4.1276"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1398-9995.2007.01515.x","article-title":"Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitis","volume":"63","author":"Fern\u00e1ndez\u2010Nieto M","year":"2008","journal-title":"Allergy"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2004.015032"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.590"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.20912","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.20912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:16:54Z","timestamp":1697033814000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.20912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,18]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/ajim.20912"],"URL":"https:\/\/doi.org\/10.1002\/ajim.20912","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,18]]}}}