{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:20:07Z","timestamp":1791148807070,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T00:00:00Z","timestamp":1287360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk of developing clinical connective tissue disease (CTD) has been reported to be increased among individuals with silica exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the medical records of individuals reported to the Michigan Silicosis Surveillance system from 1985 to 2006 to confirm the diagnosis of silicosis and determine the presence of CTDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1985 to 2006, 1,022 cases were confirmed to have silicosis. Medical records of 790 cases were available. Thirty\u2010three individuals had rheumatoid arthritis (RA) [prevalence 4.2% (prevalence ratio (RR) ranged from 2.26, 95% CI: 1.57\u20133.25 to 6.96, 95% CI: 2.93\u201316.53) depending on the reference rate used], two had scleroderma [prevalence 0.3% (RR 28.3, 95% CI: 6.09\u2013129.98)], one had systemic lupus erythematosus [prevalence 0.1% (RR 2.53, 95% CI: 0.30\u201321.64)], two had Sjogrens syndrome [prevalence 0.3% (RR 0.42, 95% CI: 0.09\u20132.08)], and six had anti\u2010neutrophil cytoplasm antibody (ANCA) vasculitis [prevalence 0.8% (RR 25.3, 95% CI: 6.34\u2013101.04)]. There was no difference between those with and without CTD with respect to age, race, industry type, history of tuberculosis, application for workers' compensation, or severity of fibrotic changes on chest X\u2010ray.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A two\u2010 to eightfold risk for RA and systemic lupus erythematosus, with a greater than 24\u2010fold risk for scleroderma and ANCA vasculitis was found in individuals with silicosis. The most common CTD among silicotics in the Michigan disease registry was RA. Though not classically included in the category of CTD, ANCA\u2010associated vasculitis was found to have a much greater prevalence amongst silicosis patients than the general population. Am. J. Ind. Med. 54:255\u2013262, 2011. \u00a9 2010 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.20917","type":"journal-article","created":{"date-parts":[[2010,10,18]],"date-time":"2010-10-18T18:15:28Z","timestamp":1287425728000},"page":"255-262","source":"Crossref","is-referenced-by-count":88,"title":["Prevalence of connective tissue disease in silicosis (1985\u20132006)\u2014a report from the state of michigan surveillance system for silicosis"],"prefix":"10.1002","volume":"54","author":[{"given":"Ashima","family":"Makol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D.","family":"Rosenman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,18]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"373","article-title":"A case of silicosis associated with polymyositis and benign monoclonal gammopathy","volume":"28","author":"Aoki A","year":"1988","journal-title":"Ryumachi"},{"key":"e_1_2_7_3_1","first-page":"435","volume-title":"Silicosis. 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