{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T23:06:18Z","timestamp":1769468778669,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T00:00:00Z","timestamp":1306800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Overexposure to carbon disulfide (CS<jats:sub>2<\/jats:sub>) has been associated with an increase in coronary heart disease, but the mechanisms mediating this effect remain unclear. We aimed to examine the relationship between CS<jats:sub>2<\/jats:sub> exposure and oxidative stress markers, in order to clarify the oxidative mechanisms involved in CS<jats:sub>2<\/jats:sub>\u2010induced atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 89 workers from a viscose rayon plant were recruited for this study, and 111 workers not exposed to CS<jats:sub>2<\/jats:sub> served as controls. Cholesterol, triglyceride, malondialdehyde (MDA), superoxide dismutase (SOD), catalase, GSH peroxidase, as well as total antioxidants were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The workers exposed to CS<jats:sub>2<\/jats:sub> had significantly higher MDA levels and lower SOD levels than the controls. The average MDA levels were 776\u2009\u00b1\u2009268.2 (240\u20131,220) in the high exposure (\u226510\u2009ppm; n\u2009=\u200938), 751.6\u2009\u00b1\u2009274 (170\u20131,320) in the low exposure (&lt;10\u2009ppm; n\u2009=\u200951), and 550.4\u2009\u00b1\u2009199 (115\u20131,050) mM in the control group (n\u2009=\u2009111). The average SOD levels were 36.5\u2009\u00b1\u200938.8 (0\u2013223.5), 39.3\u2009\u00b1\u200938.8 (0\u2013160), and 58.8\u2009\u00b1\u200960.8 (5.25, 400)\u2009U\/ml in the high exposure\u2010, low exposure\u2010, and control group, respectively. MDA level increased significantly at a cumulative CS<jats:sub>2<\/jats:sub> exposure of over 60 ppm\u2010years. Dyslipoproteinemia was borderline significantly associated with CS<jats:sub>2<\/jats:sub> exposure and MDA level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results indicate that CS<jats:sub>2<\/jats:sub> exposure can induce oxidative stress as well as reduce the levels of antioxidative enzymes, and that a cumulative exposure level of 60 ppm\u2010years may be a threshold value for the oxidative and the antioxidant response. Am. J. Ind. Med. 54:637\u2013645, 2011. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.20971","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T18:39:24Z","timestamp":1306867164000},"page":"637-645","source":"Crossref","is-referenced-by-count":11,"title":["Blood oxidative stress in taiwan workers exposed to carbon disulfide"],"prefix":"10.1002","volume":"54","author":[{"given":"Jiin\u2010Chyuan 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