{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:16:07Z","timestamp":1790871367541,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T00:00:00Z","timestamp":1340236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We documented previously that if study quality is accounted for, evidence from occupational cohort studies on benzene supports a possible association with some lymphoma subtypes, in particular multiple myeloma, and acute and chronic lymphocytic leukemia. Here, we extend these analyses to chronic myeloid leukemia (CML).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three strategies to assess study quality (stratification by the year\u2010of\u2010start of follow\u2010up, stratification by the strength of the reported acute myeloid leukemia (AML) association, and stratification by the quality of benzene exposure assessment) were employed in a meta\u2010analysis of occupational benzene exposure and CML. We hypothesized that stratification by these study quality dimensions would identify a subgroup of occupational cohort studies that is most informative for the evaluation of the possible association between benzene and CML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall meta\u2010relative risk (mRR) was non\u2010significantly elevated (1.23; 95% confidence interval (CI): 0.93\u20131.63). The mRRs increased with increasing study quality for all dimensions with a significant elevation for studies with start of follow\u2010up after 1970 (1.67; 95% CI: 1.02\u20132.74). The highest study quality stratum for AML significance and exposure quality showed an elevated but non\u2010significant increased mRR (1.40; 95% CI: 0.86\u20132.27, and 1.68; 95% CI: 0.74\u20133.84, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although limited by low statistical power, the current meta\u2010analysis provides support for a possible association of occupational exposure to benzene and the risk of CML. Am. J. Ind. Med. 55:779\u2013785, 2012. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajim.22087","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T17:34:07Z","timestamp":1340300047000},"page":"779-785","source":"Crossref","is-referenced-by-count":62,"title":["Occupational benzene exposure and the risk of chronic myeloid leukemia: A meta\u2010analysis of cohort studies incorporating study quality dimensions"],"prefix":"10.1002","volume":"55","author":[{"given":"Jelle","family":"Vlaanderen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Kromhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00037-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.58.11.722"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.1066"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.57.6.411"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.56.3.174"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/mer080"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000082001.05563.e0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10090"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_12_1","first-page":"1229","article-title":"Mortality updates (1970\u20131997) of two refinery\/petrochemical plant cohorts at Baton Rouge, Louisiana, and Baytown, Texas","volume":"46","author":"Huebner WW","year":"2004","journal-title":"J Occup Environ Med"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-9-31"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-007-9065-x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.08.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2004.11.013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.60.12.918"},{"key":"e_1_2_6_18_1","first-page":"220","article-title":"Excess leukemia in a refinery population","volume":"27","author":"McCraw DS","year":"1985","journal-title":"J Occup Med"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1371.065"},{"key":"e_1_2_6_20_1","unstructured":"RothmanKJ BoiceJD.1979.Epidemiologic analysis with a programmable calculator. 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