{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:52:46Z","timestamp":1772128366347,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T00:00:00Z","timestamp":1347494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bioavailable iron (BAI) in coal, which may play a key role in causing coal workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals. Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals, possibly explaining the lower CWP prevalence among Western miners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured effects of calcite on BAI in non\u2010cellular and cellular systems involving Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor and markers of epithelial mesenchymal transition (EMT) and inflammation in mice exposed to PA coal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Calcite rapidly eliminated BAI in an aqueous suspension of PA coal. Ferritin induction in human lung epithelial cells exposed to PA coal was effectively eliminated by calcite. Mouse lung tissue markers indicated increased EMT after exposure to PA coal dust, but not after exposure to PA coal plus calcite. Markers of inflammation increased following exposure to PA coal alone, but not following exposure to PA coal plus calcite.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Additional research may lead to the use of supplemental calcite in coal mining as a safe and effective way to prevent CWP among Appalachian coal miners. Am. J. Ind. Med. 56:292\u2013299, 2013. \u00a9 2012 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22114","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T14:15:12Z","timestamp":1347545712000},"page":"292-299","source":"Crossref","is-referenced-by-count":7,"title":["Laboratory studies of the impact of calcite on in vitro and in vivo effects of coal dust: A potential preventive agent for coal workers' pneumoconiosis?"],"prefix":"10.1002","volume":"56","author":[{"given":"Meena","family":"Aladdin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinlong","family":"Jian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lung\u2010Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Finkelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,13]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"675","article-title":"Silicosis and coal workers' pneumoconiosis","volume":"108","author":"Castranova V","year":"2000","journal-title":"Environ Health Perspect"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.261055070"},{"issue":"1","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/ajcn\/53.1.106","article-title":"Calcium supplementation: Effect on iron absorption","volume":"53","author":"Cook JD","year":"1991","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31821aa000"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"95","article-title":"Variability of biological responses to silicas: Effect of origin, crystallinity, and state of surface on generation of reactive oxygen species and morphological transformation of mammalian cells","volume":"20","author":"Fubini B","year":"2001","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.03.008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.5099\/aj110200095"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937400701600552"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx00039a025"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx970151o"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7679"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063376"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39675"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200320530"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605669103"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813450701318583"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2009.050757"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2009.047126"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181a01ada"},{"key":"e_1_2_7_23_1","unstructured":"NIOSH.2008.Work\u2010related lung disease surveillance report 2007. 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