{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:40:29Z","timestamp":1790415629902,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Coal workers' pneumoconiosis (CWP) is characterized by progressive pulmonary fibrosis. Inflammation is crucial in the host response to silica and it contributes to pulmonary fibrosis. Cyclooxygenase\u20102 is involved in this process. The association between single\u2010nucleotide polymorphisms in cyclooxygenase\u20102 gene with pneumoconiosis risk was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An association study was conducted by analyzing two single\u2010nucleotide polymorphisms of cyclooxygenase\u20102 (rs689466 and rs20417) in a case\u2013control study involving 90 patients and 90 healthy individuals (controls). Genotyping was performed by the TaqMan method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rs689466 AG and GG and rs689466 GC polymorphisms were significantly less frequent in patients than in controls. Cyclooxygenase\u20102 rs689466 and rs20417 variant genotypes exhibited 21% and 12% decreased CWP risk, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cyclooxygenase\u20102 rs689466 and rs20417 polymorphisms were associated with CWP risk. Am. J. Ind. Med. 57:866\u2013871, 2014. \u00a9 2014 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22335","type":"journal-article","created":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T23:21:16Z","timestamp":1401924076000},"page":"866-871","source":"Crossref","is-referenced-by-count":7,"title":["Polymorphisms in cyclooxygenase\u20102 gene and risk of developing coal workers' pneumoconiosis: A case\u2013control study"],"prefix":"10.1002","volume":"57","author":[{"given":"Lu\u2010Qin","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Pneumoconiosis, Shanghai Pulmonary Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pneumoconiosis, Shanghai Pulmonary Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pneumoconiosis, Shanghai Pulmonary Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Bi","sequence":"additional","affiliation":[{"name":"Department of Pneumoconiosis, Shanghai Pulmonary Hospital, School of Medicine Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2009.11.006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(92)90074-T"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803933105"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156995"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1063"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450607"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001090000094"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01624.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2006.47.1.15"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02715.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971215)50:6<937::AID-JNR4>3.0.CO;2-E"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181a01ada"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(03)00037-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287390902841102"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06455-8"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000030340.80207.C5"},{"key":"e_1_2_5_19_1","first-page":"3785","article-title":"Expression of cyclooxygenase\u20101 and \u20102 in human colorectal cancer","volume":"55","author":"Sano H","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022624"},{"key":"e_1_2_5_21_1","first-page":"4997","article-title":"Expression of cyclooxygenase\u20102 in human lung carcinoma","volume":"58","author":"Wolff H","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-200204000-00019"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.05.003"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.071"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.22335","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.22335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T15:43:38Z","timestamp":1696607018000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.22335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/ajim.22335"],"URL":"https:\/\/doi.org\/10.1002\/ajim.22335","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]}}}