{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:28:04Z","timestamp":1779895684550,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Rationale<\/jats:title><jats:p>Obliterative bronchiolitis in former coffee workers prompted a cross\u2010sectional study of current workers. Diacetyl and 2,3\u2010pentanedione levels were highest in areas for flavoring and grinding\/packaging unflavored coffee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We interviewed 75 (88%) workers, measured lung function, and created exposure groups based on work history. We calculated standardized morbidity ratios (SMRs) for symptoms and spirometric abnormalities. We examined health outcomes by exposure groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SMRs were elevated 1.6\u2010fold for dyspnea and 2.7\u2010fold for obstruction. The exposure group working in both coffee flavoring and grinding\/packaging of unflavored coffee areas had significantly lower mean ratio of forced expiratory volume in 1\u2009s to forced vital capacity and percent predicted mid\u2010expiratory flow than workers without such exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current workers have occupational lung morbidity associated with high diacetyl and 2,3\u2010pentanedione exposures, which were not limited to flavoring areas. Am. J. Ind. Med. 58:1235\u20131245, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22533","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T13:46:55Z","timestamp":1446472015000},"page":"1235-1245","source":"Crossref","is-referenced-by-count":45,"title":["Respiratory morbidity in a coffee processing workplace with sentinel obliterative bronchiolitis cases"],"prefix":"10.1002","volume":"58","author":[{"given":"Rachel L.","family":"Bailey","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Respiratory Health Division, Field Studies Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Cox\u2010Ganser","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Respiratory Health Division, Field Studies Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Duling","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Respiratory Health Division, Field Studies Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan F.","family":"LeBouf","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Respiratory Health Division, Field Studies Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Stephen B.","family":"Martin","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Respiratory Health Division, Field Studies Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni A.","family":"Bledsoe","sequence":"additional","affiliation":[{"name":"CDC, NIOSH, Health Effects Laboratory Division Allergy and Clinical Immunology Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett J.","family":"Green","sequence":"additional","affiliation":[{"name":"CDC, NIOSH, Health Effects Laboratory Division Allergy and Clinical Immunology Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Kreiss","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Respiratory Health Division, Field Studies Branch Morgantown WV"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf020724p"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00013903"},{"key":"e_1_2_7_4_1","first-page":"395","article-title":"Bronchiolitis associated with exposure to artificial butter flavoring in workers at a cookie factory in Brazil","volume":"38","author":"Cavalcanti Zdo R","year":"2012","journal-title":"J Bras Pneumol"},{"key":"e_1_2_7_5_1","unstructured":"Centers for Disease Control and Prevention. 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