{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T11:55:19Z","timestamp":1721649319330},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>New light is being shed on the relationship between chronic neurotoxicity of the central nervous system (CNS) and exposure to low\u2010level organic solvents (OS). However, there are few longitudinal studies with a large sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of OS\u2010exposed male workers was selected who had undergone an OS\u2010associated specialized medical check\u2010up at least once between 2000 and 2004 in Korea. The standardized admission ratios (SAR) for CNS diseases were calculated with reference to the Korean adult male population. Adjusted relative risks (ARR) were also estimated in comparison to noise\u2010exposed male workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 238,574 OS\u2010exposed workers, yielding 954,772 person\u2010years of exposure. OS\u2010exposed workers were at elevated risk of \u201cother extrapyramidal and movement disorders\u201d (G25) with a SAR\u2009=\u20092.95 (95% CI: 1.41\u20135.42) and \u201csystemic atrophies primarily affecting the CNS\u201d (G10\u2013G13) SAR\u2009=\u20092.08 (95% CI: 1.03\u20133.74). There were no significant differences between the OS\u2010exposed workers and noise\u2010exposed workers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A limited number of CNS diseases identified through hospital admissions data and short observation periods reduced statistical power to determine effect size. OS exposure was positively associated with \u201cother extrapyramidal and movement disorder and systemic atrophies primarily affecting the CNS. Am. J. Ind. Med. 59:392\u2013398, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22568","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T04:44:51Z","timestamp":1456375491000},"page":"392-398","source":"Crossref","is-referenced-by-count":3,"title":["Central nervous system diseases of organic solvents exposed workers based on nationwide medical surveillance\u2010data in Korea"],"prefix":"10.1002","volume":"59","author":[{"given":"Young\u2010Sun","family":"Min","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine Dongguk University Gyeongju Hospital Gyeongju\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon\u2010Soon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Dongguk University Ilsan Hospital Goyang\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22032"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051506"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.01.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2005.022400"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2008.07.072"},{"key":"e_1_2_9_8_1","first-page":"1102","volume-title":"Environmental and occupational medicine","author":"Fiedler NL","year":"2007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22629"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-008-0341-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f88191"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2012.42.1.10"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117370"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199607000-00015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.11.016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000145600.91491.F2"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355344"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009070"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199803000-00011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2006.12.004"},{"key":"e_1_2_9_21_1","unstructured":"ParkB.2002. 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