{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T01:55:22Z","timestamp":1719107722383},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While low dose computed tomography (LDCT) screening for lung cancer is recommended for high\u2010risk smokers, ages 55\u201374 years, information about asbestos exposure may not be routinely elicited. Asbestos exposure is associated with declining respiratory function over time; however, the effect of a history of asbestos exposure in LDCT screening cohorts is limited. We report the relationship between asbestos exposure and pulmonary function in a cohort of heavy smokers with a history of occupational asbestos exposure, hypothesizing that these subjects will have additional decreased pulmonary function. We also examined relationships between spirometric measurements and the presence of isolated pleural plaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed using data from the NYU Lung Cancer Biomarker Center cohort to compare study subjects with a history asbestos exposure primarily in the period since 1970 when tighter federal standards were in place (n\u2009=\u2009359) to those without asbestos exposure (n\u2009=\u20091038) with respect to pulmonary function, LDCT lung imaging findings, and clinical symptoms. We further classified individuals with asbestos exposure by length of exposure time to examine the effect of duration of exposure on pulmonary function. Lastly, for asbestos\u2010exposed participants, we examined the association of spirometric measurements with the presence of absence of isolated pleural plaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with asbestos exposure had decreased FVC % predicted compared to those with no asbestos exposure (76% vs. 85% predicted, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01) and FEV<jats:sub>1<\/jats:sub> % predicted (64% vs. 67% predicted, <jats:italic>P\u2009<\/jats:italic>&lt;\u20090.01). Since there was no change in FEV<jats:sub>1<\/jats:sub>\/FVC ratio, the findings are consistent with restrictive impairment. Those with \u226520 years of exposure had a lower mean FVC % predicted compared to those with less than 20 years of exposure (74% vs. 78% predicted, <jats:italic>P<\/jats:italic>\u2009=\u20090.017). Individuals with asbestos exposure were more likely to have pleural plaques (<jats:italic>P\u2009<\/jats:italic>&lt;\u20090.001) on CT. Those with isolated pleural plaques had lower mean % predicted FEV<jats:sub>1<\/jats:sub> (<jats:italic>P\u2009<\/jats:italic>=\u20090.005) and FVC (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) compared to those without pleural plaques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Occupational asbestos exposure in a cohort of heavy smokers was associated with a significant restrictive decline in pulmonary function, with longer duration of exposure associated with greater decline. The presence of isolated pleural plaques was also associated with reduced lung function. Am. J. Ind. Med. 59:178\u2013185, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22571","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T13:34:38Z","timestamp":1453901678000},"page":"178-185","source":"Crossref","is-referenced-by-count":8,"title":["Reduced lung function in smokers in a lung cancer screening cohort with asbestos exposure and pleural plaques"],"prefix":"10.1002","volume":"59","author":[{"given":"Sarah","family":"Lopatin","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Department of Medicine New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Chieh","family":"Tsay","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, and Sleep Medicine Department of Medicine New York University School of Medicine New York New 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