{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:08:58Z","timestamp":1770336538227,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Small airway dysfunction occurs following WTC dust exposure, but its role in producing symptoms is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Methacholine challenge (MCT) was used to assess the relationship between onset of respiratory symptoms and small airway abnormalities in 166 symptomatic WTC dust\u2010exposed patients. Forced oscillation testing (FOT) and respiratory symptoms were assessed during MCT. FOT parameters included resistance at 5 and 20\u2009Hz (R<jats:sub>5<\/jats:sub> and R<jats:sub>20<\/jats:sub>) and the R<jats:sub>5<\/jats:sub> minus R<jats:sub>20<\/jats:sub> (R<jats:sub>5\u201320<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline spirometry was normal in all (mean FEV<jats:sub>1<\/jats:sub> 100\u2009+\u200913% predicted, mean FEV<jats:sub>1<\/jats:sub>\/FVC 80\u2009+\u20094%). MCT revealed bronchial hyperreactivity by spirometry in 67 patients. An additional 24 patients became symptomatic despite minimal FEV<jats:sub>1<\/jats:sub> change (&lt;5%); symptom onset coincided with increased R<jats:sub>5<\/jats:sub> and R<jats:sub>5\u201320<\/jats:sub> (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.001 vs. baseline). The dose\u2013response of FOT (reactivity) was greater compared with subjects that remained asymptomatic (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FOT during MCT uncovered reactivity in small airways as a mechanism for respiratory symptoms in subjects with inhalational lung injury. Am. J. Ind. Med. 59:767\u2013776, 2016. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22639","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T11:24:32Z","timestamp":1472729072000},"page":"767-776","source":"Crossref","is-referenced-by-count":16,"title":["Isolated small airway reactivity during bronchoprovocation as a mechanism for respiratory symptoms in WTC dust\u2010exposed community members"],"prefix":"10.1002","volume":"59","author":[{"given":"Kenneth I.","family":"Berger","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine NYU School of Medicine New York New York"},{"name":"Andre Cournand Pulmonary Physiology Laboratory Bellevue Hospital New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Kalish","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, 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