{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:01:55Z","timestamp":1793412115205,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006225","name":"Oak Ridge Associated Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006225","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The beryllium lymphocyte proliferation test (BeLPT), has become the principal clinical test for detecting beryllium sensitization and chronic beryllium disease. Uninterpretable BeLPT results can occur in a small but significant proportion of tests from poor lymphocyte growth (PG) or over proliferation of lymphocytes (OP). The clinical and laboratory causes of uninterpretable results are not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BeLPT data from the US Department of Energy\u2010supported Former Worker Screening Program were analyzed for a 10\u2010year period. Drivers of uninterpretable BeLPTs were investigated using multivariable models and classification techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three participant attributes were significantly associated with PG, while OP showed no significant associations. Serum lot for the lymphocyte growth medium accounted for 21% of the variation in PG and 16% in OP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum lots influence the likelihood of having uninterpretable BeLPT. To better understand uninterpretable results and possibly reduce their occurrence, additional laboratory\u2010related factors should be addressed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22842","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T05:46:17Z","timestamp":1521956777000},"page":"592-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and laboratory factors contributing to uninterpretable beryllium lymphocyte proliferation tests (BeLPT)"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-2477","authenticated-orcid":false,"given":"Derek E.","family":"Smith","sequence":"first","affiliation":[{"name":"Cancer Center Biostatistics Core University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9430-7702","authenticated-orcid":false,"given":"Ashley P.","family":"Golden","sequence":"additional","affiliation":[{"name":"Oak Ridge Associated Universities Oak Ridge Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Stange","sequence":"additional","affiliation":[{"name":"Oak Ridge Associated Universities Arvada Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Barker","sequence":"additional","affiliation":[{"name":"National Jewish Health Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Mroz","sequence":"additional","affiliation":[{"name":"National Jewish Health Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Bar\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashis","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Informatics Colorado School of Public Health University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Maier","sequence":"additional","affiliation":[{"name":"National Jewish Health Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Cragle","sequence":"additional","affiliation":[{"name":"Oak Ridge Associated Universities Oak Ridge Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S.","family":"Newman","sequence":"additional","affiliation":[{"name":"Center for Health, Work, and Environment, and Department of Environmental and Occupational Health and Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-190OC"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.publhealth.28.021406.144011"},{"key":"e_1_2_13_4_1","first-page":"953","article-title":"Significance of the blood beryllium lymphocyte proliferation test","volume":"104","author":"Newman L","year":"1996","journal-title":"Environ Health Perspect"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20082"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20909"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20548"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00439-0"},{"key":"e_1_2_13_9_1","unstructured":"DOE2001. 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