{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:57:04Z","timestamp":1768265824442,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Municipality of Manfredonia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In 1976 in Manfredonia (Italy), arsenic was released into the atmosphere due to an accident in a petrochemical plant. We aimed to analyze the mortality of workers involved in the factory for the site cleaning activities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort consisted of 1467 workers grouped into contract, fertilizer, and plastic workers. The outcome of interest was mortality for specific causes. Standardized mortality ratios (SMR) and 95% confidence intervals (95%CI) were computed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all workers and all causes of death combined, the SMR was less than 1.0. Mortality ratios were increased for malignant neoplasms of the pleura, bone and melanoma of the skin. Contract workers, the group mostly exposed to arsenic, showed statistically significant SMRs for several malignancies, in particular for lung cancer (SMR\u2009=\u20091.26; 95%CI: 1.05\u20101.54).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, the results reported here on mortality among persons occupationally exposed to arsenic are consistent with the literature and biologically plausible.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22939","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T19:14:26Z","timestamp":1546629266000},"page":"145-155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term effect of arsenic exposure: Results from an occupational cohort study"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-0752","authenticated-orcid":false,"given":"Emilio Antonio L.","family":"Gianicolo","sequence":"first","affiliation":[{"name":"Italian National Research Council Institute of Clinical Physiology Lecce Italy"},{"name":"University of Mainz Institute of medical Biostatistics, Epidemiology and Informatics Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mangia","sequence":"additional","affiliation":[{"name":"Italian National Research Council Institute of Atmospheric Sciences and Climate Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4226-8537","authenticated-orcid":false,"given":"Marco","family":"Cervino","sequence":"additional","affiliation":[{"name":"Italian National Research Council Institute of Atmospheric Sciences and Climate Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Bruni","sequence":"additional","affiliation":[{"name":"Epidemiological and Statistical Unit Azienda Sanitaria Locale Taranto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Portaluri","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy General Hospital Brindisi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Comba","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Pirastu","sequence":"additional","affiliation":[{"name":"Fondazione Sapienza Universit\u00e0 di Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annibale","family":"Biggeri","sequence":"additional","affiliation":[{"name":"Department of Statistics, Computer Science, Applications University of Florence Florence Italy"},{"name":"Epidemiologia e Prevenzione Social Enterprise Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela","family":"Vigotti","sequence":"additional","affiliation":[{"name":"Italian National Research Council Institute of Clinical Physiology Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Blettner","sequence":"additional","affiliation":[{"name":"University of Mainz Institute of medical Biostatistics, Epidemiology and Informatics Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"IARC.A review of human carcinogens. 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