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We report two Lynch syndrome patients with paraoccupational asbestos exposure who developed diffuse malignant mesothelioma of the pleura or peritoneum. Interestingly, one showed a separate focus of pleural well\u2010differentiated papillary mesothelioma. It is likely that Lynch syndrome patients are at increased risk for the development of mesothelioma in the setting of exposure to asbestos, even at what is generally considered to be low levels. In the presence of a documented history of low\u2010level asbestos exposure, patients with genetic predisposition disorders (including Lynch syndrome) should be considered to have an independent risk factor modifying the effects of asbestos exposure.<\/jats:p>","DOI":"10.1002\/ajim.22968","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T10:33:50Z","timestamp":1556620430000},"page":"448-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Malignant mesothelioma in Lynch syndrome: A report of two cases and a review of the literature"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-5997","authenticated-orcid":false,"given":"Angela R.","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-8671","authenticated-orcid":false,"given":"Richard L.","family":"Kradin","sequence":"additional","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital Boston Massachusetts"},{"name":"Department of Pulmonary and Critical Care Medicine Massachusetts General Hospital Boston Massachusetts"},{"name":"Department of Internal Medicine Massachusetts General Hospital Boston 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