{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:59Z","timestamp":1740104219358,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the frequency and severity of pleuropulmonary alterations in anthophyllite\u2010exposed former workers in Itapira, S\u00e3o Paulo, Brazil. The amphibole anthophyllite, a magnesium\u2010iron silicate, had its mining, marketing, and use forbidden in Brazil in 1995.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Former workers were followed from 1999 to 2011. All completed chest X\u2010ray interpreted using the International Labour Office (ILO) classification. High\u2010resolution computed tomography was used at the final evaluation. Spirometry assessed forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and FEV1\/FVC throughout the follow\u2010up period. Samples from the mined ore were analyzed by X\u2010ray diffraction (XRD) and scanning electron microscopy coupled to energy dispersive spectroscopy (SEM\u2010EDS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>XRD and SEM\u2010EDS confirmed the presence in ore of anthophyllite at a concentration of 75%, in addition to tremolite and other amphiboles in lower concentrations. Twenty\u2010eight subjects were evaluated. Median time of exposure was 3 years (minimum\u2009=\u20091; maximum\u2009\u2009=\u200918; interquartile interval\u2009=\u20091\u20104). Twenty cases of pleural abnormalities were diagnosed in 26 evaluated (77%). The average latency time was 25.6\u2009\u00b1\u20097.4 years. Two individuals (7.7%) showed progressive worsening of diffuse pleural thickening (DPT) and exhibited an annual FVC decrease of 85\u2009mL and 150\u2009mL, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This small sample showed a very high index of nonmalignant pleural abnormalities in anthophyllite\u2010exposed workers compared with workers exposed to other kinds of fibers. Rapidly progressive DPT, defined by the severity of pleural compromise, was possibly secondary to the presence of other amphibole types in the inhaled dust. No significant loss of FVC was found in the studied group as a whole. No cases of asbestosis, lung carcinoma, and mesothelioma were diagnosed in this cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.22977","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T13:49:21Z","timestamp":1556804961000},"page":"503-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High frequency and severity of pleural changes in former workers exposed to anthophyllite associated with other contaminating amphibole asbestos in Brazil"],"prefix":"10.1002","volume":"62","author":[{"given":"Ronaldo Ferreira","family":"Macedo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology School of Medicine, University of Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elza Maria Figueiras Pedreira","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Division of Radiology Regional Hospital of Sumar\u00e9, University of Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Algranti","sequence":"additional","affiliation":[{"name":"Division of Medicine FUNDACENTRO, Ministry of Labor  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dailto","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Mineral Quantification, Department of Geology and Natural Resources Institute of Geosciences, University of Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-6971","authenticated-orcid":false,"given":"Eduardo Mello","family":"De Capitani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology School of Medicine, University of Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,2]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_1_2_1","DOI":"10.1056\/NEJM198906293202604"},{"unstructured":"Brasil. 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