{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:17:23Z","timestamp":1790381843625,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005220","name":"Agency for Toxic Substances and Disease Registry","doi-asserted-by":"publisher","award":["1U61TS000179"],"award-info":[{"award-number":["1U61TS000179"]}],"id":[{"id":"10.13039\/100005220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lung cancer screening with low\u2010dose computed tomography (CT) scanning (LDCT) is accepted as a screening tool, but its application to populations exposed to recognized occupational or environmental carcinogens is limited. We apply LDCT to a population with a predominantly nonoccupational exposure to a recognized human lung carcinogen, Libby amphibole asbestos (LA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients in an asbestos disease clinic in Libby, Montana who were aged 50 to 84 years, greater than or equal to 20 pack\u2010year history of tobacco use (irrespective of quit date), and asbestos\u2010related pleuropulmonary disease on high\u2010resolution CT scan were offered free annual lung cancer screening over a 39\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2897 clinic patients, 1149 (39.7%) met eligibility criteria, and 567 (49%) were screened with 1014 low\u2010dose CT scans. Most screened patients had principally environmental (333 or 59%) or household exposure (145 or 25%) to LA. Seventeen primary lung cancers were identified, mostly in early stages: 10 at stage 1, two at stage 2, three at stages 3 to 4, and two at limited small\u2010cell cancers. The screening yield was 1.9 at baseline scan and 1.5% on the first annual scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consistent with the guidelines of the National Comprehensive Cancer Network and American Association of Thoracic Surgery, LDCT for early lung cancer detection should be offered to people with significant exposure to occupational or environmental human lung carcinogens.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23042","type":"journal-article","created":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T06:29:56Z","timestamp":1568874596000},"page":"1112-1116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lung cancer screening in patients with Libby amphibole disease: High yield despite predominantly environmental and household exposure"],"prefix":"10.1002","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7185-0796","authenticated-orcid":false,"given":"Gregory","family":"Loewen","sequence":"first","affiliation":[{"name":"Washington State University  Spokane Washington"},{"name":"Center for Asbestos\u2010Related Disease  Libby Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Black","sequence":"additional","affiliation":[{"name":"Center for Asbestos\u2010Related Disease  Libby Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-1114","authenticated-orcid":false,"given":"Tracy","family":"McNew","sequence":"additional","affiliation":[{"name":"Center for Asbestos\u2010Related Disease  Libby Montana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Miller","sequence":"additional","affiliation":[{"name":"Barry Commoner Center for the Environment and Health, Queens College 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