{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:55:47Z","timestamp":1790506547267,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA\u2010176726"],"award-info":[{"award-number":["UM1 CA\u2010176726"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["R01 OH\u2010010359"],"award-info":[{"award-number":["R01 OH\u2010010359"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exposure to disinfectants among healthcare workers has been associated with respiratory health effects, in particular, asthma. However, most studies are cross\u2010sectional and the role of disinfectant exposures in asthma development requires longitudinal studies. We investigated the association between occupational exposure to disinfectants and incident asthma in a large cohort of U.S. female nurses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Nurses\u2019 Health Study II is a prospective cohort of 116\u2009429 female nurses enrolled in 1989. Analyses included 61\u2009539 participants who were still in a nursing job and with no history of asthma in 2009 (baseline; mean age: 55 years). During 277\u2009744 person\u2010years of follow\u2010up (2009\u20102015), 370 nurses reported incident physician\u2010diagnosed asthma. Occupational exposure was evaluated by questionnaire and a Job\u2010Task\u2010Exposure Matrix (JTEM). We examined the association between disinfectant exposure and subsequent asthma development, adjusted for age, race, ethnicity, smoking status, and body mass index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Weekly use of disinfectants to clean surfaces only (23% exposed) or to clean medical instruments (19% exposed) was not associated with incident asthma (adjusted hazard ratio [95% confidence interval] for surfaces, 1.12 [0.87\u20101.43]; for instruments, 1.13 [0.87\u20101.48]). No association was observed between high\u2010level exposure to specific disinfectants\/cleaning products evaluated by the JTEM (formaldehyde, glutaraldehyde, bleach, hydrogen peroxide, alcohol quats, or enzymatic cleaners) and asthma incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a population of late career nurses, we observed no significant association between exposure to disinfectants and asthma incidence. A potential role of disinfectant exposures in asthma development warrants further study among healthcare workers at earlier career stage to limit the healthy worker effect.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23067","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T11:44:20Z","timestamp":1573040660000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Occupational exposure to disinfectants and asthma incidence in U.S. nurses: A prospective cohort study"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-2826","authenticated-orcid":false,"given":"Orianne","family":"Dumas","sequence":"first","affiliation":[{"name":"INSERM, U1168, VIMA\u2010Aging and Chronic Diseases Epidemiological and Public Health Approaches Villejuif France"},{"name":"UMR\u2010S 1168 Univ Versailles St\u2010Quentin\u2010en\u2010Yvelines Montigny le 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