{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:31:42Z","timestamp":1787974302652,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asbestos is the primary known cause of malignant mesothelioma. Some cosmetic talc products have been shown to contain asbestos. Recently, repeated exposures to cosmetic talc have been implicated as a cause of mesothelioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five individuals (64 females; 11 males) with malignant mesothelioma, whose only known exposure to asbestos was repeated exposures to cosmetic talcum powders, were reviewed in medical\u2010legal consultation. Out of the 75 cases, 11 were examined for asbestiform fibers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All subjects had pathologically confirmed malignant mesothelioma. The mean age at diagnosis was 61\u2009\u00b1\u200917 years. The mean latency from exposure to diagnosis was 50 \u00b1\u200913 years. The mean exposure duration was 33\u2009\u00b1\u200916 years. Four mesotheliomas (5%) occurred in individuals working as barbers\/cosmetologists, or in a family member who swept the barber shop. Twelve (16%) occurred in individuals less than 45 years old (10 females; 2 males). Forty\u2010eight mesotheliomas were pleural (40 females; 8 males), 23 were peritoneal (21 females; 2 males). Two presented with concomitant pleural and peritoneal disease. There was one pericardial, and one testicular mesothelioma. The majority (51) were of the epithelioid histological subtype, followed by 13 biphasic, 8 sarcomatoid, 2 lymphohistiocytoid, and 1 poorly differentiated. Of the 11 individuals whose nontumorous tissues were analyzed for the presence of asbestiform fibers, all showed the presence of anthophyllite and\/or tremolite asbestos.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mesotheliomas can develop following exposures to cosmetic talcum powders. These appear to be attributable to the presence of anthophyllite and tremolite contaminants in cosmetic talcum powder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23106","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T09:30:01Z","timestamp":1584351001000},"page":"484-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Malignant mesothelioma following repeated exposures to cosmetic talc: A case series of 75 patients"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8075-4480","authenticated-orcid":false,"given":"Theresa S.","family":"Emory","sequence":"first","affiliation":[{"name":"Department of Pathology Peninsula Pathology Associates  Newport News Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-0337","authenticated-orcid":false,"given":"John C.","family":"Maddox","sequence":"additional","affiliation":[{"name":"Department of Pathology Peninsula Pathology Associates  Newport News Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-8671","authenticated-orcid":false,"given":"Richard L.","family":"Kradin","sequence":"additional","affiliation":[{"name":"Department of Medicine (Pulmonary\/Critical Care) Massachusetts General Hospital  Boston Massachusetts"},{"name":"Department of Pathology Massachusetts General Hospital  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.17.4.260"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203744"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0274(200103)39:3<262::AID-AJIM1014>3.0.CO;2-R"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31077"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.74995"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287397609529432"},{"key":"e_1_2_9_8_1","first-page":"65","article-title":"Asbestos form impurities in commercial talcum powders","volume":"49","author":"Snider D","year":"1972","journal-title":"Compass Sigma Gamma Epsilon"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1179\/2049396714Y.0000000081"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000001723"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000001800"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0273-2300(84)90022-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/mef056"},{"key":"e_1_2_9_14_1","first-page":"257","article-title":"Pneumoconiosis due to talc in the cosmetic industry","volume":"3","author":"Millman N.","year":"1947","journal-title":"Occup Med"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(73)90026-1"},{"key":"e_1_2_9_16_1","unstructured":"Johns\u2010Manville Research and Engineering Center.Body Talcum Powders\u2014Petrographic Examination requested by J. P. Leineweber. 31 October1968.https:\/\/cdn.toxicdocs.org\/gb\/gbq4wMVNy39gQpYQoRr0EpBE3\/gbq4wMVNy39gQpYQoRr0EpBE3.pdf. Accessed 29 February 2020."},{"key":"e_1_2_9_17_1","unstructured":"LewinS New York University to Alfred Weissler FDA August 3 1972 https:\/\/cdn.toxicdocs.org\/85\/85JyymOw7EB568x1mExoqRQVe\/85JyymOw7EB568x1mExoqRQVe.pdf. Accessed 29 February 2020."},{"key":"e_1_2_9_18_1","first-page":"447","article-title":"Asbestos and other ferruginous bodies their formation and clinical significance","volume":"102","author":"Churg AM","year":"1981","journal-title":"Am J Pathol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821201)50:11<2423::AID-CNCR2820501130>3.0.CO;2-I"},{"key":"e_1_2_9_20_1","unstructured":"American Cancer Society.Key Statistics About Malignant Mesothelioma;2018.https:\/\/www.cancer.org\/cancer\/malignant\u2010mesothelioma\/about\/key\u2010statistics.html. 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