{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:54:02Z","timestamp":1790916842229,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T00:00:00Z","timestamp":1590883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intramural Research Program of the National Institutes of Health, National Cancer Institute, and the U.S. Public Health Service of the Department of Health and Human Services"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While international agreement supports a causal relationship of benzene exposure with acute myeloid leukemia, there is debate about benzene and lymphoid neoplasm risks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a case\u2010cohort study with follow\u2010up of 110\u2009631 Chinese workers during 1972\u20101999, we evaluated benzene exposure\u2010response for non\u2010Hodgkin lymphoma (NHL), lymphoid leukemias (LL), acute lymphocytic leukemia (ALL), and total lymphoid neoplasms (LN). We estimated benzene exposures using state\u2010of\u2010the\u2010art hierarchical modeling of occupational factors calibrated with historical routine measurements and evaluated cumulative exposure\u2010response using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NHL and other specified LN were increased in exposed vs unexposed workers. However, there was no evidence of exposure\u2010response for NHL or other specified LN. Based on a linear exposure\u2010response, relative risks at 100 parts per million\u2010years (RR at 100\u2009ppm\u2010years) for cumulative benzene exposure using a 2\u2010year lag (exposure at least 2\u2009years before the time at risk) were 1.05 for NHL (95 percent confidence interval (CI)\u2009=\u20090.97, 1.27; 32 cases), 1.11 for LL (95% CI\u2009&lt;\u20090, 1.66; 12 cases), 1.21 for ALL (95% CI\u2009&lt;\u20090, 3.53; 10 cases), and 1.02 for total LN (95% CI\u2009&lt;\u20090, 1.16; 49 cases). No statistically significant exposure\u2010response trends were apparent for these LN for 2 to &lt;10\u2010year or \u226510\u2010year lags. NHL risks were not significantly modified by sex, age, or year at first exposure, attained age, or time since exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the study strengths and limitations, we found little evidence of exposure\u2010response for benzene and NHL, LL, ALL, or total LN, although NHL and other specified LN were increased in exposed vs unexposed individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23142","type":"journal-article","created":{"date-parts":[[2020,5,31]],"date-time":"2020-05-31T13:35:01Z","timestamp":1590932101000},"page":"741-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Benzene exposure\u2010response and risk of lymphoid neoplasms in Chinese workers: A multicenter case\u2010cohort study"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1687-5587","authenticated-orcid":false,"given":"Martha S.","family":"Linet","sequence":"first","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel S.","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Division of Environmental Epidemiology, Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a M.","family":"Dores","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS Rockville Maryland"},{"name":"Analytic Epidemiology Branch, Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research US Food and Drug Administration Silver Spring Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2010Nian","family":"Yin","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and Prevention Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutzen","family":"Portengen","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences Utrecht University Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Population Health New York University School of Medicine New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bu\u2010Tian","family":"Ji","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lan","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui\u2010Lan","family":"Li","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and Prevention Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Rothman","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, NIH, DHHS Rockville Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,31]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Chemicals and Industrial Processes Associated with Cancer in Humans, Vol. 1 to 20, Benzene","author":"IARC","year":"2018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2010.508162"},{"issue":"1","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/annhyg\/mer080","article-title":"Combining a job\u2010exposure matrix with exposure measurements to assess occupational exposure to benzene in a 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