{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T01:36:47Z","timestamp":1770341807825,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The use of low dose CT (LDCT) chest is becoming more widespread in occupationally exposed populations. There is a knowledge gap as to heterogeneity in severity and the natural course of asbestosis after low levels of exposure. This study reports the characteristics of LDCT\u2010detected interstitial lung abnormalities (ILA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Asbestos Review Program offers annual LDCT, health assessments, and pulmonary function tests to an asbestos\u2010exposed cohort. Asbestosis was defined using the Helsinki Consensus statement and the presence of ILA defined using a protocol for occupational CT reports. At least two of three pulmonary function tests: forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>);\u200b forced vital capacity (FVC); and diffusion capacity for carbon monoxide (DLco) were required for analysis of physiological decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1513 cases, radiological ILA was present in 485 (32%). The cohort was 83.5% male with a median age of 68.3 years and a median (IQR) asbestos exposure of 0.7 (0.09\u20132.32) fiber\/ml\u2010year. A mixed occupation, mixed asbestos fiber cohort comprised the majority of the cohort (65.8%). Of those with ILA, 40 (8.2%) had an FVC decline of \u226510% and 30 (6.2%) had a DLco decline of \u226515% per year. Time since first exposure, increasing tobacco exposure and reported dyspnea were independently associated with the presence of ILA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this population with relatively low asbestos exposure, LDCT\u2010detected ILA that fits criteria for asbestosis is common, but physiological decline is not. This mild chronic stable phenotype of asbestos\u2010associated ILA contrasts with the traditionally accepted views that asbestosis requires high exposures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23251","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T02:28:01Z","timestamp":1620095281000},"page":"567-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Low dose CT detected interstitial lung abnormalities in a population with low asbestos exposure"],"prefix":"10.1002","volume":"64","author":[{"given":"Edward J. 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