{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:58:13Z","timestamp":1763445493928},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","award":["U01 OH011489"],"award-info":[{"award-number":["U01 OH011489"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The World Trade Center (WTC) attack exposed thousands of workers to toxic chemicals that have been linked to liver diseases and cancers. This study examined the relationship between the intensity of WTC dust exposure and the risk of hepatic steatosis in the WTC General Responders Cohort (GRC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All low\u2010dose computed tomography (CT) scans of the chest performed on the WTC GRC between September 11, 2001 and December 31, 2018, collected as part of the World Trade Center Health Program, were reviewed. WTC dust exposure was categorized into five groups based on WTC arrival time. CT liver density was estimated using an automated algorithm, statistics\u2010based liver density estimation from imaging. The relationship between the intensity of WTC dust exposure and the risk of hepatic steatosis was examined using univariate and multivariable regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1788 WTC responders, 258 (14.4%) had liver attenuation less than 40 Hounsfield units (HU\u2009&lt;\u200940) on their earliest CT. Median time after September 11, 2001 and the earliest available CT was 11.3 years (interquartile range: 8.0\u201314.9 years). Prevalence of liver attenuation\u00a0less than 40 HU was 17.0% for arrivals on September 11, 2001, 16.0% for arrivals on (September\u00a012, 2001 or September\u00a013, 2001), 10.9% for arrivals on September 14\u201330, 2001, and 9.0% for arrivals on January 10, 2001 or later (<jats:italic>p<\/jats:italic>\u2009=\u20090.0015). A statistically significant trend of increasing liver steatosis was observed with earlier arrival times (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). WTC arrival time remained a significant independent factor for decreased liver attenuation after controlling for other covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early arrival at the WTC site was significantly associated with increasing hepatic steatosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23269","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T11:04:32Z","timestamp":1627643072000},"page":"837-844","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dose\u2010response relationship between World Trade Center dust exposure and hepatic steatosis"],"prefix":"10.1002","volume":"64","author":[{"given":"Artit","family":"Jirapatnakul","sequence":"first","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowena","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea D.","family":"Branch","sequence":"additional","affiliation":[{"name":"Division of Liver Diseases,\u00a0Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David F.","family":"Yankelevitz","sequence":"additional","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia I.","family":"Henschke","sequence":"additional","affiliation":[{"name":"Department of Radiology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.02110703"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2019.12.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(20)34243-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20170959"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300155"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140754"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29367"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.108723"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.19391"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190512"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3284530"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.06.024"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6702"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9592"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357900600633965"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.9775"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.488057"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200679"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17197290"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0881-3.00027-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312468517"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-019-00232-w"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181dfda78"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb51081.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2016-104051"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23321"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.23269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ajim.23269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.23269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:02:09Z","timestamp":1693285329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.23269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/ajim.23269"],"URL":"https:\/\/doi.org\/10.1002\/ajim.23269","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]},"assertion":[{"value":"2021-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}