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This study determined the prevalence of work\u2010related symptoms, allergic sensitization, and lung function abnormalities in HWs of two tertiary hospitals in Southern Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study of 699 HWs (South Africa: SAH, <jats:italic>n<\/jats:italic>\u2009=\u2009346; Tanzania: TAH, <jats:italic>n<\/jats:italic>\u2009=\u2009353) was conducted. Health outcomes were assessed using a standardized ECRHS questionnaire, immunological tests (specific IgE antibody to common aero\u2010allergens and to occupational allergens: natural rubber latex [NRL]\u00a0 Hev b5 and Hev b6.02, chlorhexidine, and ortho\u2010phthalaldehyde [OPA]), spirometry [pre\u2010and post\u2010 bronchodilator], methacholine challenge, and fractional exhaled nitric oxide (FeNO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A large proportion of participants (78%) were women. Median age was 42 years, with 76% nurses, 12% cleaners, and 5% administrative workers. Current smoking was more common in SAHWs (12%) than TAHWs (1%). The overall prevalence of doctor\u2010diagnosed asthma was 7%. Atopy was present in 43% of HWs, while 4% were sensitized to OPA, 2% to NRL, and 1% to chlorhexidine. Prevalence of work\u2010related ocular\u2010nasal symptoms (16%) was higher than skin (12%) and chest (7%) symptoms. TAHWs had significantly lower mean lung volumes, higher degrees of significant airflow obstruction and impaired lung function. The prevalence of bronchial hyperresponsiveness in SAHWs (14%) was high. Overall, 23% of HWs had abnormal FeNO; 6% having high (&gt;50 ppb) levels. FeNO was positively associated with sensitization to occupational allergens, primarily OPA and NRL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HWs from both hospitals had similar prevalence of work\u2010related respiratory symptoms. Sensitization to OPA and NRL appears to be contributing to allergic airway inflammation in these HWs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23344","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T16:24:59Z","timestamp":1646929499000},"page":"382-395","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Work\u2010related allergy and asthma associated with cleaning agents in health workers in Southern African tertiary hospitals"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2002-9700","authenticated-orcid":false,"given":"Hussein H.","family":"Mwanga","sequence":"first","affiliation":[{"name":"Division of Occupational Medicine, Centre for Environmental and Occupational Health Research, School of Public Health and Family Medicine University of Cape Town Cape Town South Africa"},{"name":"Department of Environmental and Occupational Health, School of Public Health and Social Sciences Muhimbili University of Health and Allied Sciences  Dar es Salaam Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-071X","authenticated-orcid":false,"given":"Roslynn","family":"Baatjies","sequence":"additional","affiliation":[{"name":"Division of Occupational Medicine, Centre for Environmental and Occupational Health Research, School of Public Health and Family Medicine University of Cape Town Cape Town South Africa"},{"name":"Department of Environmental and Occupational Studies, Faculty of Applied Sciences Cape Peninsula University of Technology Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-087X","authenticated-orcid":false,"given":"Tanusha","family":"Singh","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Health National Health Laboratory Services Johannesburg South Africa"},{"name":"Department of Environmental Health, School of Health Sciences University of Johannesburg Johannesburg South Africa"},{"name":"Department of Clinical Microbiology and Infectious Diseases, School of Pathology University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6656-9193","authenticated-orcid":false,"given":"Mohamed F.","family":"Jeebhay","sequence":"additional","affiliation":[{"name":"Division of Occupational Medicine, Centre for Environmental and Occupational Health Research, School of Public Health and Family Medicine University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Republic of South Africa. 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