{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:02:31Z","timestamp":1783144951181,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Potential reproductive effects of organic solvent exposure during pregnancy remain unclear. We investigated the association between maternal occupational exposure during pregnancy to six chlorinated solvents, three aromatic solvents, and Stoddard solvent, and delivery of preterm infants or those born small\u2010for\u2010gestational age (SGA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2013control study of SGA and preterm birth (PTB) nested within the National Birth Defects Prevention Study (NBDPS) from 1997 to 2011, we analyzed data from 7504 singleton live births without major birth defects and their mothers. Self\u2010reported information on jobs held in the periconceptional period was assessed for solvent exposure. Unconditional logistic regression was used to estimate the association between maternal occupational exposure (any, none) during early pregnancy to organic solvents and PTB and SGA. Linear regression was used to examine changes in mean birthweight potentially associated with maternal occupational solvent exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal occupational exposure to any organic solvents overall was not associated with an increased odds of PTB (adjusted odds ratio [aOR]\u2009=\u20090.94; 95% confidence interval [CI] 0.67\u20131.33) or SGA (aOR\u2009=\u20090.93; 95% CI 0.65\u20131.34). Point estimates increased modestly for higher estimated exposure versus lower, but confidence intervals were wide and not statistically significant. Maternal exposure to solvents was not associated with a statistically significant change in term birthweight among infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Occupational exposure to organic solvents at the frequency and intensity levels found in a population\u2010based sample of pregnant workers was not associated with PTB or SGA; however, we cannot rule out any effects among pregnant workers with uncommonly high exposure to organic solvents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23516","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T02:56:05Z","timestamp":1689735365000},"page":"842-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal occupational exposure to selected organic and chlorinated solvents and delivery of small\u2010for\u2010gestational age or preterm infants"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-6882","authenticated-orcid":false,"given":"Kristen W.","family":"Van Buren","sequence":"first","affiliation":[{"name":"Division of Field Studies and Engineering National Institute for Occupational Safety and Health Cincinnati Ohio USA"},{"name":"Department of Epidemiology and Environmental Health, College of Public Health University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa M.","family":"Rocheleau","sequence":"additional","affiliation":[{"name":"Division of Field Studies and Engineering National Institute for Occupational Safety and Health Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-8395","authenticated-orcid":false,"given":"I\u2010Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Field Studies and Engineering National Institute for Occupational Safety and Health Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania A.","family":"Desrosiers","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne T.","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Department of Biosystems and Agricultural Engineering, College of Agriculture, Food and Environment University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Politis","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Ailes","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The National Birth Defects Prevention Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Organic Solvents. 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