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Organic solvents are used widely in the workplace and exposure may increase the risk of developing breast cancer, yet there are insufficient data to confirm this hypothesis. We sought to determine whether past occupational exposures to selected organic solvents were associated with the incidence of invasive breast cancer in postmenopausal women in Montr\u00e9al, Canada.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a population\u2010based case\u2013control study (2008\u20132011), using in\u2010depth interviews we elicited information on risk factors and lifetime occupational histories. Industrial hygienists and chemists translated job descriptions into specific chemical and physical exposures. We assessed 11 individual solvents and four solvent groups. Unconditional logistic regression was used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for metrics of past exposures to selected solvents. Exposure metrics included any previous exposure, average frequency in hours per week, duration in years, and average cumulative concentration weighted by hours per workweek exposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 695 cases and 608 controls. We found increased ORs for average cumulative concentration of exposure to mononuclear aromatic hydrocarbons (OR: 1.52, 95%\u00a0CI: 1.04, 2.28), chlorinated alkanes (OR: 2.42, 95%\u00a0CI: 1.23, 5.68), toluene (OR: 1.59, 95%\u00a0CI: 1.02, 2.59), and a group of organic solvents with reactive metabolites (OR: 1.53, 95%\u00a0CI: 1.08, 2.24). Positive associations were found across all exposure metrics and were higher among women with estrogen\u2010positive\/progesterone\u2010negative tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest occupational exposure to certain organic solvents may increase the risk of incident postmenopausal breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23525","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T11:23:53Z","timestamp":1691753033000},"page":"911-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The association between the incidence of postmenopausal breast cancer and occupational exposure to selected organic solvents, Montreal, Canada, 2008\u20132011"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6955-8778","authenticated-orcid":false,"given":"Sydney","family":"Westra","sequence":"first","affiliation":[{"name":"Department of Epidemiology Biostatistics and Occupational Health McGill University Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics and Occupational Health McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Medicine McGill University Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8722-0433","authenticated-orcid":false,"given":"France","family":"Labr\u00e8che","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health School of Public Health and Centre de recherche en sant\u00e9 publique (CReSP) University of Montr\u00e9al and CIUSSS Centre\u2010Sud Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Institut de recherche Robert\u2010Sauv\u00e9 en sant\u00e9 et en s\u00e9curit\u00e9 du travail Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Biostatistics and Occupational Health McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Ethics, Equity and Policy McGill University Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikki","family":"Ho","sequence":"additional","affiliation":[{"name":"Health Innovation and Evaluation Hub Universit\u00e9 de Montr\u00e9al Hospital Research Centre (CRCHUM) Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Social and Preventive Medicine Universit\u00e9 de Montr\u00e9al School of Public Health (ESPUM) Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.212097"},{"key":"e_1_2_12_3_1","volume-title":"Breast cancer. 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