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Concerns about possible adverse effects have appeared in many publications, particularly since the COVID\u201019 pandemic led to much more widespread use. This paper synthesizes known effects based upon review of publications in PubMed since 1995, addressing effects other than pulmonary and cardiovascular (reviewed elsewhere). Findings: (1) Subjective discomfort is very frequently reported; this includes general discomfort or organ\u2010system\u2010specific complaints such as respiratory, headache, dermatologic, and heat. Research methods are widely divergent, and we propose a taxonomy to classify such studies by methodology, study population (subjects, experimental vs. observational methodology, comparator, specificity, and timeframe) to facilitate synthesis. (2) Objective measures of increased heat and humidity within the mask are well documented. (3) Frequency and characteristics of dermatologic effects have been insufficiently evaluated. (4) Physical mask designs are varied, making generalizations challenging. (5) More studies of impact on work performance and communication are needed. (6) Studies of effect of FFR design and accompanying training materials on ease and consistency of use are needed.<\/jats:p>","DOI":"10.1002\/ajim.23535","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:29:15Z","timestamp":1694604555000},"page":"1017-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Health effects of filtering facepiece respirators: Research and clinical implications of comfort, thermal, skin, psychologic, and workplace effects"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-4989","authenticated-orcid":false,"given":"Philip","family":"Harber","sequence":"first","affiliation":[{"name":"Environmental Health Sciences University of Arizona Mel and Enid Zuckerman College of Public Health Tucson Arizona 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