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Fifty\u2010two Italian asbestos cohorts (asbestos\u2010cement, rolling\u2010stock, shipbuilding, and other) were pooled and their mortality follow\u2010up was updated to 2018. Standardized mortality ratios (SMRs) were computed for major causes of death considering duration of exposure and time since first exposure (TSFE), using reference rates by region, age and calendar period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 63,502 subjects (57,156 men and 6346 women): 40% who were alive, 58% who died (cause known for 92%), and 2% lost to follow\u2010up. Mortality was increased for all causes (SMR: men\u2009=\u20091.04, 95% confidence interval [CI] 1.03\u22121.05; women\u2009=\u20091.15, 95% CI 1.11\u22121.18), all malignancies (SMR: men\u2009=\u20091.21, 95% CI 1.18\u22121.23; women\u2009=\u20091.29, 95% CI 1.22\u22121.37), pleural and peritoneal malignancies (men: SMR\u2009=\u200910.46, 95% CI 9.86\u221211.09 and 4.29, 95% CI 3.66\u22125.00; women: SMR\u2009=\u200927.13, 95% CI 23.29\u221231.42 and 7.51, 95% CI 5.52\u22129.98), lung (SMR: men\u2009=\u20091.28, 95% CI 1.24\u22121.32; women\u2009=\u20091.26, 95% CI 1.02\u22121.53), and ovarian cancer (SMR\u2009=\u20091.42, 95% CI 1.08\u22121.84). Pleural cancer mortality increased during the first 40 years of TSFE (latency), reaching a plateau thereafter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Analyses by time\u2010dependent variables showed that the risk for pleural neoplasms increased with latency and no longer increases at long TSFE, consistent with with asbestos clearance from the lungs. Peritoneal neoplasm risk increased over all observation time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23546","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T11:55:20Z","timestamp":1697716520000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cause specific mortality in an Italian pool of asbestos workers cohorts"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-3759","authenticated-orcid":false,"given":"Daniela","family":"Ferrante","sequence":"first","affiliation":[{"name":"Department of Translational Medicine Universit\u00e0 del Piemonte Orientale and CPO Piemonte Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Angelini","sequence":"additional","affiliation":[{"name":"Institute for Cancer Research, Prevention and Clinical Network (ISPRO) Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9205-6455","authenticated-orcid":false,"given":"Fabiano","family":"Barbiero","sequence":"additional","affiliation":[{"name":"Department of Medical Area (DAME) University of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Barbone","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Bauleo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Lazio Regional Health Service Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0435-600X","authenticated-orcid":false,"given":"Alessandra","family":"Binazzi","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Epidemiology and Hygiene, Italian Workers' Compensation Authority Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bovenzi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Clinical Unit of Occupational Medicine, University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Istituto Superiore di Sanit\u00e0 Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Casotto","sequence":"additional","affiliation":[{"name":"Epidemiological Department Azienda Zero Padova Veneto Region Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2397-5586","authenticated-orcid":false,"given":"Achille","family":"Cernigliaro","sequence":"additional","affiliation":[{"name":"Regional Health Authority of Sicily Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Ceppi","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit IRCCS\u2010Ospedale Policlinico San Martino Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Cervino","sequence":"additional","affiliation":[{"name":"Department of Public Health Azienda USL di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Chellini","sequence":"additional","affiliation":[{"name":"ex ISPRO Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Curti","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Santis","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Istituto Superiore di Sanit\u00e0 Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Fazzo","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Istituto Superiore di Sanit\u00e0 Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-3398","authenticated-orcid":false,"given":"Ugo","family":"Fedeli","sequence":"additional","affiliation":[{"name":"Epidemiological Department Azienda Zero Padova Veneto Region Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germano","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Unit of Occupational Medicine\u2014Istituto Nazionale Tumori\u2014IRCCS\u2014Fondazione G. 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