{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:27:33Z","timestamp":1786976853922,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004343","name":"3M","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exposure to per\u2010 and polyfluoroalkyl substances (PFAS) has been associated with several health outcomes, though few occupationally\u2010exposed populations have been studied. We evaluated mortality and cancer incidence in a cohort of perfluorooctanesulfonyl fluoride\u2010based specialty chemical manufacturing workers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The cohort included any employee who ever worked at the facility from 1961 to 2010 (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094045), with a primary interest in those who had 365 cumulative days of employment (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20092659). Vital status and mortality records were obtained through 2014 and the cohort was linked to state cancer registries to obtain incident cancer cases from 1995 to 2014. Cumulative exposure was derived from a comprehensive exposure reconstruction that estimated job\u2010specific perfluorooctanesulfonate (PFOS)\u2010equivalents (mg\/m\n                      <jats:sup>3<\/jats:sup>\n                      ) exposure. Overall and exposure\u2010specific standardized mortality ratios (SMR) were estimated in reference to the US population. Hazard ratios (HRs) and 95% confidence interval (CI) for cumulative PFOS\u2010equivalent exposure (log\n                      <jats:sub>2<\/jats:sub>\n                      transformed) were estimated within the cohort for specific causes of death and incident cancers using a time\u2010dependent Cox model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Death rates were lower than expected except for cerebrovascular disease (SMR\u2009=\u20092.42, 95% CI\u2009=\u20091.25\u20134.22) and bladder cancer (SMR\u2009=\u20093.91, 95% CI\u2009=\u20091.07\u201310.02) in the highest exposure quartile. Within the cohort, the incidence of bladder, colorectal, and pancreatic cancer were positively associated with exposure, however except for lung cancer (HR\u2009=\u20091.05, 95% CI\u2009=\u20091.00\u20131.11) the CIs did not exclude an HR of 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides some evidence that occupational exposure to PFOS is associated with bladder and lung cancers and with cerebrovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ajim.23568","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T09:34:43Z","timestamp":1707730483000},"page":"321-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mortality and cancer incidence in perfluorooctanesulfonyl fluoride production workers"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9523-1914","authenticated-orcid":false,"given":"Bruce H.","family":"Alexander","sequence":"first","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.","family":"Church","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health University of Minnesota Minneapolis Minnesota USA"},{"name":"Masonic Cancer Center University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-9532","authenticated-orcid":false,"given":"Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Environmental Health Sciences, School of Public Health University of Minnesota Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geary W.","family":"Olsen","sequence":"additional","affiliation":[{"name":"3M Corporate Occupational Medicine St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry W.","family":"Logan","sequence":"additional","affiliation":[{"name":"3M Corporate Industrial Hygiene (retired) St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR).Toxicological Profile for Perfluoroalkyls.U.S. Department of Health and Human Services Public Health Service.2021. Accessed September 2022.https:\/\/www.atsdr.cdc.gov\/ToxProfiles\/tp200.pdf"},{"key":"e_1_2_12_2_2","doi-asserted-by":"crossref","unstructured":"doi:10.15620\/cdc:59198","DOI":"10.15620\/cdc:59198"},{"key":"e_1_2_12_3_1","volume-title":"Perfluoro\u2010Octanoic Acid, Tetrafluoroethylene, Dichloromethane, 1,2\u2010Dichloropropane, 1,3\u2010Propane Sultone","author":"International Agency for Research on Cancer","year":"2017"},{"key":"e_1_2_12_4_1","volume-title":"Perfluorooctanoic acid (PFOA) and Perfluorooctanesulfonic acid (PFOS)","author":"International Agency for Research on Cancer","year":"2023"},{"key":"e_1_2_12_5_1","first-page":"822P23007","volume-title":"PUBLIC COMMENT DRAFT Toxicity Assessment and Proposed Maximum Contaminant Level Goal for Perfluorooctane Sulfonic Acid (PFOS) in Drinking Water","author":"United States Environmental Protection Agency (USEPA)","year":"2023"},{"key":"e_1_2_12_6_1","first-page":"822P23005","volume-title":"PUBLIC COMMENT DRAFT Toxicity Assessment and Proposed Maximum Contaminant Level Goal for Perfluorooctanoic Acid (PFOA) in Drinking Water","author":"United States Environmental Protection Agency (USEPA)","year":"2023"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.23362"},{"key":"e_1_2_12_8_1","unstructured":"Agency for Toxic Substances and Disease Registry. PFAS in the US Population2022. Accessed March 30 2023.https:\/\/www.atsdr.cdc.gov\/pfas\/health-effects\/us-population.html"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.23454"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws171"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.60.10.722"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181b5f395"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000052958.59271.10"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/15428110308984859"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.01.036"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3180582043"},{"key":"e_1_2_12_17_1","volume-title":"A Strategy for Assessing and Managing Occupational Exposure","author":"Jahn SD","year":"2015"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.02.029"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20999"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280206074463"},{"key":"e_1_2_12_21_1","volume-title":"SAS Software Version 9.4","author":"SAS","year":"2019"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2021.112217"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.01.003"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.02.017"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1306615"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.06.011"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2014-102109"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110690"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws588"},{"key":"e_1_2_12_30_1","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR).Toxicological profile for Fluorides Hydrogen Fluoride and Fluorine.U.S. Department of Health and Human Services Public Health Service.2003. Accessed September 2022.https:\/\/www.atsdr.cdc.gov\/ToxProfiles\/tp.asp?id=212&tid=38"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx349"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx348"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-019-00230-y"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-45"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2013.10.005"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-10-88"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaa143"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP12603"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.04.001"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31821d0879"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2014-102364"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164119892223"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-020-00656-0"},{"key":"e_1_2_12_44_1","unstructured":"Centers for Disease Control and Prevention National Center for Health Statistics. Underlying Cause of Death 1999\u20132017 on CDC WONDER Online Database.2018. Accessed April 2021.https:\/\/wonder.cdc.gov\/ucd-icd10.html"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.22933"},{"key":"e_1_2_12_46_1","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR). Exposure Investigation Report: Perfluorochemical Serum Sampling in the Vicinity of Decatur Alabama Morgan Lawrence and Limestone Counties.U.S. Department of Health and Human Services Public Health Service.2013. Accessed November 2023.https:\/\/www.atsdr.cdc.gov\/HAC\/pha\/Decatur\/Perfluorochemical_Serum%20Sampling.pdf"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.23568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T08:46:08Z","timestamp":1710405968000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.23568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,12]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ajim.23568"],"URL":"https:\/\/doi.org\/10.1002\/ajim.23568","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,12]]},"assertion":[{"value":"2023-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}