{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:54:10Z","timestamp":1791500050230,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological studies of occupational risk factors for rare disorders require large study populations with adequate exposure estimates. Job exposure matrices (JEMs) linked to national information on standardized job titles may enable such large studies. We aimed to establish and validate a JEM for occupational hand\u2010wrist exposures that could be linked to Danish national register data on job titles and hand\u2010wrist disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a JEM for hand\u2010wrist repetition, force, vibration, and computer work in 96 job groups covering 91% of the 2227 occupational titles in the Danish version of the International Standard Classification of Occupation\u201088, and examined inter\u2010rater reliability of five expert ratings. Poisson regression models were used to estimate incidence rate ratios for the association of carpal tunnel syndrome (CTS) with the level of repetitive movements, force, vibration, and hours of computer work described by the JEM, adjusted for relevant confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The JEM based on expert ratings had fair to good interrater reliability. The incidence of CTS increased with increasing levels of force, hand\u2010wrist repetition, and vibration, Exposure\u2010response patterns for repetition and vibration became less consistent after adjustment for force. The interaction between repetition and force was complex and did not support an overall positive interaction. Computer work was negatively associated with incident CTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The JEM was able to identify known risk factors for CTS consistent with current evidence, and provided further associations on exposure\u2010response patterns, mutual exposure adjustment, and interaction effects between repetition and force. The reliability of expert assessments of hand\u2010wrist physical exposures was fair to good.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23651","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T03:09:12Z","timestamp":1724728152000},"page":"942-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validity of an expert\u2010based job exposure matrix of hand\u2010wrist physical exposures and their prospective associations with carpal tunnel syndrome"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-4144","authenticated-orcid":false,"given":"Jonathan Aavang","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine Bispebjerg Hospital Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Fr\u00f8lund","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Bispebjerg Hospital Copenhagen 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