{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:48:39Z","timestamp":1785473319088,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the utility of the beryllium lymphocyte proliferation test (BeLPT), distinguishing sarcoidosis, a disease of unknown etiology, from chronic beryllium disease (CBD), has long posed a diagnostic challenge. It is unclear if beryllium\u2010exposed sarcoidosis cases (Be\u2010exp\u2010Sarc) are clinically distinct from CBD, or are misdiagnosed cases of CBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a case\u2010case study of 40 beryllium\u2010exposed individuals diagnosed with Be\u2010exp\u2010Sarc compared to 40 frequency\u2010matched CBD cases. We compared demographics, exposure, clinical, physical, and radiographic characteristics and HLA DBPI E69 genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to CBD, Be\u2010exp\u2010Sarc cases were diagnosed at a younger age, had lower lung function, were less likely to have normal radiographic imaging, were more likely to have massive adenopathy and extra\u2010thoracic manifestations and were more likely to have been prescribed systemic immunosuppressive therapy. Be\u2010exp\u2010Sarc tended to have fewer years of beryllium exposure, but there were no significant differences in the amount of beryllium exposure. HLA DPBI E69 was present in 53% of Be\u2010exp\u2010Sarc cases, not different from the general population, versus 92% of CBD cases (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While a number of differences were observed, the only absolute distinguishing features were lack of confirmed beryllium sensitization in Be\u2010exp\u2010Sarc and lack of extra\u2010thoracic manifestations in CBD. These findings suggest that Be\u2010exp\u2010Sarc may be distinct from CBD, and beryllium or some other workplace exposure may possibly play an as yet to be defined etiologic role, although the possibility that these cases could be due to selection bias from heightened surveillance in beryllium workforces cannot be excluded.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ajim.23676","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T11:29:45Z","timestamp":1732534185000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sarcoidosis in Beryllium Exposed Workers: A Case\u2010Case Study"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2766-375X","authenticated-orcid":false,"given":"Annyce S.","family":"Mayer","sequence":"first","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences, Department of Medicine National Jewish Health Denver Colorado USA"},{"name":"Department of Environmental and Occupational Health Colorado School of Public Health, University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5252-5990","authenticated-orcid":false,"given":"Margaret M.","family":"Mroz","sequence":"additional","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences, Department of Medicine National Jewish Health Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-6190","authenticated-orcid":false,"given":"Michael K.","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences, Department of Medicine National Jewish Health Denver Colorado USA"},{"name":"Department of Environmental and Occupational Health Colorado School of Public Health, University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-5446","authenticated-orcid":false,"given":"Karin A.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Division of Environmental and Occupational Health Sciences, Department of Medicine National Jewish Health Denver Colorado USA"},{"name":"Department of Environmental and Occupational Health Colorado School of Public Health, University of Colorado Anschutz Medical Campus Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3000-5610","authenticated-orcid":false,"given":"E. 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