{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:31:26Z","timestamp":1774661486275,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T00:00:00Z","timestamp":1168473600000},"content-version":"vor","delay-in-days":9872,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of a four\u2010hour exposure (via a Plexiglas hood) to sulfur dioxide (SO<jats:sub>2<\/jats:sub>) on airway reactivity was studied in both normal and allergic conscious sheep. Allergic sheep were defined as animals in whom inhalation of <jats:italic>Ascaris suum<\/jats:italic> extract resulted in an increase in mean pulmonary flow resistance (R<jats:sub>L<\/jats:sub>). Airway reactivity (\u03b4R<jats:sub>L<\/jats:sub>) was assessed by measuring the increase in R<jats:sub>L<\/jats:sub> after 18 breaths of 0.25% carbachol, from an initial value obtained after 18 breaths of buffered saline. R<jats:sub>L<\/jats:sub> and \u03b4R<jats:sub>L<\/jats:sub> were determined prior to, immediately after and 24 hours following SO<jats:sub>2<\/jats:sub> exposure in three groups of sheep: six normal sheep exposed to 5 ppm SO<jats:sub>2<\/jats:sub> (group A); six normal sheep exposed to 10 ppm SO<jats:sub>2<\/jats:sub> (group B) and seven allergic sheep exposed to 5 ppm SO<jats:sub>2<\/jats:sub> (group C). R<jats:sub>L<\/jats:sub> was not affected by SO<jats:sub>2<\/jats:sub> exposure in any group but both groups B and C showed increases in \u03b4R<jats:sub>L<\/jats:sub> 24 hours after exposure. Since the increase in \u03b4R<jats:sub>L<\/jats:sub> was greater in group C than in either groups A or B, we conclude that allergic sheep have enhanced susceptibility to the injurious airway effects of SO<jats:sub>2<\/jats:sub>.<\/jats:p>","DOI":"10.1002\/ajim.4700010315","type":"journal-article","created":{"date-parts":[[2007,4,15]],"date-time":"2007-04-15T03:19:21Z","timestamp":1176607161000},"page":"383-390","source":"Crossref","is-referenced-by-count":3,"title":["Sulfur dioxide induced airway hyperreactivity in allergic sheep"],"prefix":"10.1002","volume":"1","author":[{"given":"William M.","family":"Abraham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Welker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryann","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillette A.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Yerger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Sielczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin A.","family":"Sackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1152\/jappl.1980.48.5.789","article-title":"The sensitivity of bronchoprovocation and tracheal mucous velocity in detecting airway responses to O3","volume":"48","author":"Abraham WM","year":"1980","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(80)90119-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(79)90095-2"},{"key":"e_1_2_1_5_1","first-page":"389","article-title":"Bronchial hyperreactivity","volume":"121","author":"Boushey HA","year":"1980","journal-title":"Am Rev Resp Dis"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.24.2.176"},{"key":"e_1_2_1_7_1","first-page":"26","article-title":"Prevalence of chronic respiratory disease in a pulp mill and a paper mill in the United States","volume":"24","author":"Ferris BG","year":"1967","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_8_1","first-page":"767","article-title":"Effects of sulfur oxide and respirable particles on human health","volume":"120","author":"Ferris BG","year":"1979","journal-title":"Am Rev Resp Dis"},{"key":"e_1_2_1_9_1","first-page":"579","article-title":"Airway responses to methacholine in allergic and non\u2010allergic subjects","volume":"113","author":"Fish JE","year":"1976","journal-title":"Am Rev Resp Dis"},{"key":"e_1_2_1_10_1","first-page":"159","article-title":"On the effects of prolonged exposure to sulphur dioxide","volume":"14","author":"Kehoe RA","year":"1932","journal-title":"J Ind Hyg"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.242.11.1163"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108281"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108314"},{"key":"e_1_2_1_14_1","unstructured":"ShyCM GoldsmithJR HackneyJD LebowitzMD MenzelDB(1978): Health effects of air pollution.ATS News:22\u201363."},{"key":"e_1_2_1_15_1","first-page":"69","article-title":"Long\u2010term effects of sulphur dioxide exposure in pulp mills","volume":"21","author":"Skalpe IO","year":"1964","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_16_1","unstructured":"US Department of Health Education and Welfare Public Health Service Center for Disease Control. National Institute for Occupational Safety and Health(1974):Criteria for a recommended standard \u2026 occupational exposure to sulfur dioxide. Washington DC."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/3429056"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/jappl.1978.44.3.479","article-title":"Respiratory mechanics in conscious sheep: response to methacholine","volume":"44","author":"Wanner A","year":"1979","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1152\/jappl.1979.47.5.917","article-title":"Antigen\u2010induced bronchospasm in conscious sheep","volume":"47","author":"Wanner A","year":"1979","journal-title":"J Appl Physiol"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700010315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700010315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T18:49:45Z","timestamp":1693507785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700010315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":18,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/ajim.4700010315"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700010315","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}