{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:15:33Z","timestamp":1792145733424,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":9514,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both subcutaneous and hepatic hemangiosarcomas were induced in mice exposed to vinyl chloride monomer, and for the first time, the ultrastructure of hemangiosarcomas related to vinyl chloride exposure has been described. The subcutaneous hemangiosarcoma developed in a mouse's ear 29 weeks after exposure to 10 ppm vinyl chloride for 4 weeks, and the hepatic hemangiosarcoma was found in a mouse's liver at necropsy 56 weeks after exposure to 600 ppm vinyl chloride for 4 weeks. Both tumors showed a localized, cystic nodular appearance with a dark red tone. Histologically, an angiomatous architecture, the presence of neoplastic mesenchymal cell aggregates, focal necrosis, and hemorrhagic foci were common. Ultrastructurally, two neoplastic cell types, a mesenchymal and a well\u2010differentiated endothelial cell type, were identified in both tumors. In addition, in the hepatic tumor, a pericyte\u2010like neoplastic cell was also present. The incidence of hemangiosarcoma was much lower than that of lung tumors (alveologenic tumor) in mice exposed to vinyl chloride at the same concentrations for the same duration. This study suggests that there is no basic difference in ultrastructure between the vinyl chloride\u2010induced hemangiosarcomas and hemangiosarcomas not related to this chemical exposure.<\/jats:p>","DOI":"10.1002\/ajim.4700020205","type":"journal-article","created":{"date-parts":[[2007,4,15]],"date-time":"2007-04-15T09:16:39Z","timestamp":1176628599000},"page":"103-117","source":"Crossref","is-referenced-by-count":7,"title":["Electron microscopic observations of hepatic and subcutaneous hemangiosarcomas induced in mice exposed to vinyl chloride monomer"],"prefix":"10.1002","volume":"2","author":[{"given":"Yasunosuke","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711220405"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/3428629"},{"key":"e_1_2_1_4_1","first-page":"213","article-title":"Angiosarcoma of the liver: Annual occurrence and aetiology in Great Britain","volume":"37","author":"Baxter PJ","year":"1980","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-84-6-717"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197810)42:4<1834::AID-CNCR2820420423>3.0.CO;2-Z"},{"key":"e_1_2_1_7_1","first-page":"150","article-title":"Angiosarcoma in the manufacture of polyvinyl chloride","volume":"16","author":"Creech JL","year":"1974","journal-title":"JCM"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/jama.1974.03240010027023","article-title":"Hepatic disease among workers at a vinyl chloride polymerization plant","volume":"203","author":"Falk H","year":"1974","journal-title":"JAMA"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.772155"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/BF03547913","article-title":"The pathology of vinyl chloride exposed mice","volume":"17","author":"Holmberg B","year":"1976","journal-title":"Acta Vet Scand"},{"key":"e_1_2_1_11_1","first-page":"2024","article-title":"Angiomatosis retinae: An ultrastructural study and lipid analysis","volume":"38","author":"Jacobiec FA","year":"1976","journal-title":"Cancer"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb51095.x"},{"key":"e_1_2_1_13_1","first-page":"1598","article-title":"\u00dcber das Auftreten von angiosarkomen der Leber des zwei Arbeittern der PVC herstellenden Industrie","volume":"31","author":"Lange CE","year":"1974","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90683-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/3428496"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287397809529640"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(74)90040-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb51094.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197601)37:1<149::AID-CNCR2820370122>3.0.CO;2-7"},{"key":"e_1_2_1_20_1","first-page":"349","article-title":"Development of hepatic angiosarcoma in man induced by vinyl chloride thorotrast and arsenic. Comparison with cases of unknown etiology","volume":"92","author":"Popper H","year":"1978","journal-title":"Am J Pathol"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(76)80007-X"},{"key":"e_1_2_1_22_1","first-page":"A35\/928","article-title":"Initial features of vinyl chloride (VC) hepatic injury","volume":"71","author":"Schaffner F","year":"1976","journal-title":"Gastroenterology"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<326::AID-CNCR2820350206>3.0.CO;2-8"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(78)90163-9"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501022920104"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197905)43:5<1664::AID-CNCR2820430516>3.0.CO;2-5"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197812)42:6<2610::AID-CNCR2820420616>3.0.CO;2-W"},{"key":"e_1_2_1_28_1","first-page":"516","article-title":"Oncogenic response of rat skin, lungs and bones to vinyl chloride","volume":"31","author":"Viola PL","year":"1971","journal-title":"Cancer Res"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810101)47:1<72::AID-CNCR2820470114>3.0.CO;2-U"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700020205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700020205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T13:44:33Z","timestamp":1699796673000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700020205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/ajim.4700020205"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700020205","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}