{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:35:51Z","timestamp":1787636151625,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T00:00:00Z","timestamp":1168473600000},"content-version":"vor","delay-in-days":9141,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fifty years ago, in 1932, skeletal fluorosis was discovered as an occupational disease in cryolite workers in Copenhagen, Denmark. Following the initial reports, new cases were identified in other industries, such as the production of aluminum and superphosphate fertilizer. In light cases of fluorosis, the bone changes are often associated with nonspecific joint and muscle pains, but the disease may be entirely asymptomatic. The fluorideinduced osteosclerosis seems to be reversible, but the long\u2010term significance of fluoride accumulation in the body is not known. Family cases of dental fluorosis have been described in children of female cryolite workers. In addition, skeletal changes have occurred in long\u2010term residents near fluoride\u2010emitting industries, and in hot areas with high, natural fluoride levels in the drinking water. Skeletal fluorosis has only played a minor role in the discussion concerning fluoridation of drinking water, however. Changing and increasing uses of fluorides have led to a renewed interest in this occupational disease.<\/jats:p>","DOI":"10.1002\/ajim.4700030215","type":"journal-article","created":{"date-parts":[[2007,4,15]],"date-time":"2007-04-15T08:18:07Z","timestamp":1176625087000},"page":"227-236","source":"Crossref","is-referenced-by-count":23,"title":["Occupational fluorosis through 50 years: Clinical and epidemiological experiences"],"prefix":"10.1002","volume":"3","author":[{"given":"Philippe","family":"Grandjean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00431313"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1941.tb15616.x"},{"key":"e_1_2_1_4_1","first-page":"967","article-title":"Musculoskeletal and respiratory disease in aluminum smelter workers","volume":"30","author":"Carnow BW","year":"1979","journal-title":"Arch Hig Rada Toksikol"},{"key":"e_1_2_1_5_1","first-page":"144","volume-title":"Fluoride and Bone","author":"Czerwinski E","year":"1978"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1963.10663433"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-197608000-00010"},{"key":"e_1_2_1_8_1","first-page":"94","article-title":"Lung cancer in a fluorspar mining community","volume":"21","author":"de Villiers AJ","year":"1964","journal-title":"Brit J Industr Med"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91332-0"},{"key":"e_1_2_1_10_1","unstructured":"EkstrandJ. (1977): Studies on the pharmacokinetics of fluoride in man. Dissertation Karolinska Institute Stockholm."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197805182982003"},{"key":"e_1_2_1_12_1","first-page":"129","volume-title":"Fluoride and Bone","author":"Franke J","year":"1978"},{"key":"e_1_2_1_13_1","first-page":"393","article-title":"Besonderheiten des verlaufs der Knochenfluorose","volume":"5","author":"Fritz H","year":"1964","journal-title":"Radiol Diagn"},{"key":"e_1_2_1_14_1","first-page":"347","article-title":"Lung cancer mortality in aluminum reduction plant workers","volume":"21","author":"Gibbs GW","year":"1979","journal-title":"J Occup Med"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1978.tb02594.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043764-197701000-00003"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/57.4.757"},{"key":"e_1_2_1_18_1","first-page":"658","volume-title":"The Diseases of Occupations","author":"Hunter D","year":"1975"},{"key":"e_1_2_1_19_1","volume-title":"Fluorides. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans","author":"IARC","year":"1982"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.222.7.783"},{"key":"e_1_2_1_21_1","first-page":"531","article-title":"Health survey of aluminum workers with special reference to fluoride exposure","volume":"14","author":"Kaltreider NL","year":"1972","journal-title":"J Occup Med"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-5-607"},{"key":"e_1_2_1_23_1","volume-title":"Fluorosis. The Health Aspects of Fluorine Compounds","author":"Largent EJ","year":"1961"},{"key":"e_1_2_1_24_1","first-page":"874","article-title":"A roentgenologic study of a human population exposed to high\u2010fluoride domestic water","volume":"74","author":"Leone NC","year":"1955","journal-title":"Am J Roentgen"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(79)90061-2"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1960.tb03649.x"},{"key":"e_1_2_1_27_1","first-page":"475","article-title":"Mortality in aluminum reduction plant workers","volume":"21","author":"Milham S","year":"1979","journal-title":"J Occup Med"},{"key":"e_1_2_1_28_1","unstructured":"M\u00f8llerIJ. (1965): Dental fluorose og Caries. Dissertation. Copenhagen: Rhodos."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(75)90081-3"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016923209134962"},{"key":"e_1_2_1_31_1","first-page":"76","volume-title":"Criteria for a Recommended Standard \u2026 Occupational Exposure to Inorganic Fluorides","author":"NIOSH","year":"1975"},{"key":"e_1_2_1_32_1","first-page":"319","volume-title":"Occupational Diseases. A Guide to Their Recognition","author":"NIOSH","year":"1977"},{"key":"e_1_2_1_33_1","volume-title":"Recommended Standard for Occupational Exposure to Inorganic Fluoride","author":"NIOSH","year":"1979"},{"key":"e_1_2_1_34_1","volume-title":"Occupational Health Guidelines for Chemical Hazards","author":"NIOSH\u2010OSHA","year":"1981"},{"key":"e_1_2_1_35_1","first-page":"115","article-title":"Nogle hidtil ukendte tilfalde af mottled enamel hos indfodte i Sydvest\u2010Gr\u00f8nland","volume":"4","author":"Pedersen PO","year":"1938","journal-title":"Tandlagebladet"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112512"},{"key":"e_1_2_1_37_1","volume-title":"Fluorine Intoxication","author":"Roholm K","year":"1937"},{"key":"e_1_2_1_38_1","volume-title":"Fluoride, Teeth and Health","author":"Royal College of Physicians","year":"1976"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00377775"},{"key":"e_1_2_1_40_1","first-page":"1271","article-title":"Auftreten von Nachbarschaftsfluorose unter der Bev\u00f6lkerung einer s\u00e4chsischen Kleinstadt","volume":"31","author":"Schmidt CW","year":"1976","journal-title":"Dt Gesundh\u2010Wesen"},{"key":"e_1_2_1_41_1","first-page":"1700","article-title":"Nachbarschaftsfluorose","volume":"31","author":"Schmidt CW","year":"1976","journal-title":"Dt Gesundh\u2010Wesen"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)91370-8"},{"key":"e_1_2_1_43_1","first-page":"295","volume-title":"Continuing Evaluation of the Use of Fluorides","author":"Taves DR","year":"1979"},{"key":"e_1_2_1_44_1","first-page":"159","volume-title":"Continuing Evaluation of the Use of Flourides","author":"Taxes DR","year":"1979"},{"key":"e_1_2_1_45_1","volume-title":"Fluorides and Human Health","author":"WHO","year":"1970"},{"key":"e_1_2_1_46_1","first-page":"9","article-title":"Fluoride and cancer","volume":"21","author":"Yiamouyiannis J","year":"1975","journal-title":"Natl Health Fed Bull"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700030215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700030215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T02:14:09Z","timestamp":1699755249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700030215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/ajim.4700030215"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700030215","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}