{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T16:11:24Z","timestamp":1768666284023,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":6958,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six patients with multiple subjective health complaints, which have been correlated with chronic exposure to formaldehyde during the course of their education and occupations, were tested for the existence of antibodies (IgE, IgM, and IgG) to formaldehyde (F) conjugated to human serum albumin (F\u2010HSA). In addition, the percentage and absolute numbers of peripheral lymphocyte subpopulations as determined by surface markers were investigated. Antibody titers to F\u2010HSA were present as follows: IgE (2 patients), IgM (3 of 4 tested patients), and IgG (5 patients). Analysis of lymphocyte subpopulations showed T\u2010helper\/suppressor (H\/S) ratios ranging from 0.8 to 3.3. All 6 patients had elevated Tal cells (antigen memory cells), whereas interleuken 2 receptor positive cells were within expected values. Following formaldehyde exposure, 5 of the patients complained of an initial flulike illness from which they have not completely recovered. The sixth individual had a history of recurrent respiratory infections and surgical removal of hyperplastic ethmoid sinus tissue. The common occurrence of anti\u2010F\u2010HSA antibodies, flulike illness, and Tal cells are interpreted as suggestive of a chronic antigenic stimulation of the immune system in these 6 patients. Further immunological work\u2010up of additional subjects and immune parameters with similar history of formaldehyde exposure and subjective health complaints is warranted.<\/jats:p>","DOI":"10.1002\/ajim.4700140411","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T19:47:36Z","timestamp":1176839256000},"page":"479-488","source":"Crossref","is-referenced-by-count":37,"title":["Antibodies and immune profiles of individuals occupationally exposed to formaldehyde: Six case reports"],"prefix":"10.1002","volume":"14","author":[{"given":"Jack D.","family":"Thrasher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Broughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Micevich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"11","article-title":"The formaldehyde fiasco: A review of scientific data","volume":"9","author":"Bardana EL","year":"1987","journal-title":"Immunol Allergy Pract"},{"key":"e_1_2_1_3_1","first-page":"463","article-title":"Specific bronchoalveolar Iavage IgG antibody in hypersensitivity pneumonitis from diphenylmethane diisocyanate","volume":"131","author":"Bascom R","year":"1985","journal-title":"Amer Rev Respir Dis"},{"key":"e_1_2_1_4_1","first-page":"393","volume-title":"Immunotoxicology and Immunopharmacology","author":"Bekesi JG","year":"1985"},{"issue":"97","key":"e_1_2_1_5_1","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"21","author":"Boyuma A","year":"1968","journal-title":"Scan J Clin Lab Invest"},{"key":"e_1_2_1_6_1","unstructured":"Breysse P(1988): The immediate and long\u2010term effects of formaldehyde.Comments Toxicol(in press)."},{"key":"e_1_2_1_7_1","unstructured":"Broughton A ThrasherJD(1988): Antibodies and altered cell mediated immunity in formaldehyde exposed humans.Comments Toxicol(in press)."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700130406"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90026-7"},{"key":"e_1_2_1_10_1","first-page":"655","volume-title":"Occupational Medicine: State of the Arts Review","author":"Cullen MR","year":"1987"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.3.1791"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4049\/jimmunol.128.1.351","article-title":"Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis","volume":"128","author":"Fox RI","year":"1982","journal-title":"J Immunol"},{"key":"e_1_2_1_13_1","first-page":"351","article-title":"Tal, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody","volume":"133","author":"Fox DA","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0160-4120(82)90049-6"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4049\/jimmunol.137.2.414","article-title":"Antigen reactive memory T cells are defined by Tal","volume":"137","author":"Hafler DA","year":"1986","journal-title":"J Immunol"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198505303122201"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.4049\/jimmunol.27.6.569","article-title":"Formaldehyde hypersensitiveness. 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