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Using this exposure matrix and detailed information of the work history, cumulative arsenic exposure could be computed for each worker. Standardized mortality ratios (SMRs) were calculated for several dose categories using age\u2010specific mortality rates from the county where the smelter was situated. A positive dose\u2010response relationship was found between cumulative arsenic exposure and lung cancer mortality with an overall SMR of 372 (304\u2013450, 95% confidence interval). The lung cancer mortality was related to the estimated average intensity of exposure to arsenic but not to the duration. No positive dose\u2010response relationship was found between arsenic and ischemic heart disease or cerebrovascular disease. There was also no evident dose\u2010response relationship between estimated exposure to sulfur dioxide and lung cancer.<\/jats:p>","DOI":"10.1002\/ajim.4700150105","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T22:17:36Z","timestamp":1176848256000},"page":"31-41","source":"Crossref","is-referenced-by-count":88,"title":["Cumulative arsenic exposure and lung cancer in smelter workers: A dose\u2010response study"],"prefix":"10.1002","volume":"15","author":[{"given":"Lars","family":"J\u00e4rup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Pershagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Wall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"8","article-title":"Arsenic exposure and mortality: A case\u2010referent study from a Swedish copper smelter","volume":"35","author":"Axelson O","year":"1978","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.2307\/2528501"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1983.10477915"},{"key":"e_1_2_1_5_1","first-page":"455","article-title":"Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure","volume":"70","author":"Brown CC","year":"1983","journal-title":"JNCI"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8350293"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4809(83)90044-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/14.1.22"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113492"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114631"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113392"},{"key":"e_1_2_1_12_1","unstructured":"IARC Monographs(1980): Some metals and metallic compounds.Int Agency Res Cancer Lyon:39\u2013141."},{"key":"e_1_2_1_13_1","first-page":"601","article-title":"Arsenic and respiratory cancer in humans: Follow\u2010up of copper smelter employees in Montana","volume":"70","author":"Lee\u2010Feldstein A","year":"1983","journal-title":"JNCI"},{"key":"e_1_2_1_14_1","first-page":"296","article-title":"Cumulative exposure to arsenic and its relationship to respiratory cancer among copper smelter employees","volume":"28","author":"Lee\u2010Feldstein A","year":"1986","journal-title":"J Occup Med"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/2684074"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a121470"},{"key":"e_1_2_1_17_1","unstructured":"National Central Bureau of Statistics(1973): Reports on statistical coordination.Classification of causes of death in Swedish statistics.11. 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