{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:01:37Z","timestamp":1772899297190,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T00:00:00Z","timestamp":1382659200000},"content-version":"vor","delay-in-days":8698,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Defense mechanisms protect the lung very well from inhaled organic dusts. With sufficient exposure to certain dusts, however, susceptible individuals develop hypersensitivity pneumonitis (HP), the organic dust toxic syndrome (ODTS), or asthma. Mucous membrane irritation (MMI) bothers some individuals inhaling grain dust. Allergic asthma is caused by IgE\u2010meditated immunologic responses to allergenic dust contaminants. ODTS can be explained by a nonimmunologic release of interleukin 1 (IL\u20101) and perhaps other endogenous pyrogens from alveolar macrophages by endotoxin or other ingredients of dusts. The pathogenesis of HP may involve IL\u20101 release combined with a specific immunological response by effector T\u2010lymphocytes. MMI may be the result of an irritant effect not involving immune responses or mediators.<\/jats:p>","DOI":"10.1002\/ajim.4700170146","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T13:38:04Z","timestamp":1382708284000},"page":"139-142","source":"Crossref","is-referenced-by-count":16,"title":["Unifying concepts underlying the effects of organic dust exposures"],"prefix":"10.1002","volume":"17","author":[{"given":"Hal B.","family":"Richerson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1978.tb01501.x"},{"key":"e_1_2_1_3_1","first-page":"332","article-title":"A critical review of the role of precipitins in hypersensitivity pneumonitis","volume":"62","author":"Burrell R.","year":"1981","journal-title":"Eur J Resp Dis"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/137.1.100"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/bmj.2.6193.757","article-title":"The concept of disease","volume":"2","author":"Campbell EJM","year":"1979","journal-title":"Br Med J"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2.2.3277884"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.03.040185.001403"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830180619"},{"key":"e_1_2_1_9_1","first-page":"95","volume-title":"Recent Advances in Mucosal Immunity","author":"Kagnoff MF","year":"1982"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02992980"},{"key":"e_1_2_1_11_1","volume-title":"De Morbis Artficum","author":"Ramazzini B.","year":"1713"},{"key":"e_1_2_1_12_1","first-page":"59","volume-title":"Pulmonary reactions to inhalation of mould dust in farmers with special reference to fever and allergic alveolitis","author":"Rask\u2010Andersen A.","year":"1988"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(81)90188-3"},{"key":"e_1_2_1_14_1","first-page":"409","article-title":"Chronic hypersensitivity pneumonitis produced in the rabbit by the adjuvant effect of inhaled muramyl dipeptide (MDP)","volume":"106","author":"Richerson HB","year":"1982","journal-title":"Am J Pathol"},{"key":"e_1_2_1_15_1","first-page":"469","article-title":"Hypersensitivity pneumonitis\u2014pathology and pathogenesis","volume":"1","author":"Richerson HB","year":"1983","journal-title":"Clin Rev Allergy"},{"key":"e_1_2_1_16_1","first-page":"281","article-title":"Immune complexes and the lung: A skeptical review","volume":"3","author":"Richerson HB","year":"1984","journal-title":"Surv Synth Pathol Res"},{"key":"e_1_2_1_17_1","first-page":"667","volume-title":"Pulmonary Diseases and Disorders,\u201d 2nd edition","author":"Richerson HB","year":"1988"},{"key":"e_1_2_1_18_1","first-page":"451","article-title":"Hypersensitivity pneumonitis\u2014general considerations","volume":"1","author":"Schatz M.","year":"1983","journal-title":"Clin Rev Allergy"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90937-2"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700170146","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700170146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T10:07:47Z","timestamp":1697969267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700170146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1002\/ajim.4700170146"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700170146","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}