{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:32:13Z","timestamp":1777109533011,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":5862,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A sensitive K\u2010X\u2010ray fluorescence (K\u2010XRF) instrument was used to measure lead levels in the tibia and patella on a series of twelve subjects who had relatively well\u2010documented histories of lead exposure and blood lead levels. For some subjects, K\u2010XRF measurements were taken at multiple points in time, and before and after chelation with EDTA (ethylenediamine tetraacetic acid). Results confirm that K\u2010XRF measured bone lead levels correspond to cumulative blood lead indices and not to current blood lead levels. Moreover, the data suggest that bone lead levels; (1) correspond to urinary lead following the EDTA mobilization test unless previous chelation has occurred; (2) rise initially after lead exposure ceases and blood lead levels decrease, probably from redistribution from soft tissue, and then fall; and (3) do not decrease with a 3\u2010 to 5\u2010day course of therapeutic EDTA chelation. K\u2010XRF levels in the patella were noted to decrease more rapidly than levels in the tibia after cessation of lead exposure, a finding that probably reflects the greater turnover of lead in trabecular bone than in cortical bone.<\/jats:p>","DOI":"10.1002\/ajim.4700200603","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T10:20:46Z","timestamp":1176978046000},"page":"723-735","source":"Crossref","is-referenced-by-count":56,"title":["Effect of repeated occupational exposure to lead, cessation of exposure, and chelation on levels of lead in bone"],"prefix":"10.1002","volume":"20","author":[{"given":"Howard","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Pepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"109","article-title":"In\u2010vivo determination of lead in the skeleton after occupational exposure to lead","volume":"37","author":"Ahlgren L","year":"1980","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700100207"},{"key":"e_1_2_1_4_1","first-page":"339","article-title":"Lead concentrations in human tissues","volume":"27","author":"Barry PSI","year":"1970","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Batuman V MaesakaJK Haddad B Tepper E Landy E WedeenRP. 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Office of Health and Environmental Assessment Environmental Criteria and Assessment Office. EPA Report no. EPA\u2010600\/ 8\u201383\/028aF\u2010dF. 4v. NTIS Springfield Va; PB 87\u2013142378"},{"key":"e_1_2_1_30_1","first-page":"155","article-title":"Blood lead\u2014An inadequate measure of occupational exposure","volume":"17","author":"Vitale LF","year":"1975","journal-title":"J Occup Med"},{"key":"e_1_2_1_31_1","first-page":"357","volume-title":"In\u2010Vivo Body Composition Studies.","author":"Wedeen RP","year":"1988"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1990.9935927"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700090304"},{"key":"e_1_2_1_34_1","unstructured":"Zaric M Prpic\u2010Majic I) Kostial K Piasec M. (1987):Exposure to lead and reproduction. In: \u201cSummary Proceedings of a Workshop: Selected Aspects of Exposure to Heavy Metals in the Environment. 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