{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:20:32Z","timestamp":1780348832727,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":5862,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the effects of styrene exposure on peripheral, central, and autonomic nervous system functions in man, we measured the distribution of nerve conduction velocities (DCV), short\u2010latency somatosensory evoked potentials (SSEP), and variability in electrocardiographic R\u2010R interval (CV<jats:sub>RR<\/jats:sub>) as well as conventional sensory and motor median nerve conduction velocities (SCV and MCV) in eleven styrene\u2010exposed workers. The styrene workers' urinary phenylglyoxylic acid levels ranged from 31 to 419 (mean 169) mg\/g creatinine at the end of the work shift on the examination day (estimated exposure to styrene of 22 ppm in air). Control subjects, matched to each styrene worker by sex and age, were selected from healthy adults without cardiovascular, neurologic and other potentially confounding disorders. In the styrene workers, we found that the V80 velocity of the DCV, below which 80% of active nerve fibers lie, and the SCV were both significantly slowed; the CV<jats:sub>RR<\/jats:sub> was also significantly reduced. There were no significant differences in SSEP latencies, MCV, or heart rate between the exposed workers and controls. These data, despite the small sample size, suggest that styrene affects the faster myelinated fibers of the peripheral sensory nerves, and that it also affects autonomic nervous activity.<\/jats:p>","DOI":"10.1002\/ajim.4700200609","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T10:40:41Z","timestamp":1176979241000},"page":"775-784","source":"Crossref","is-referenced-by-count":55,"title":["Assessment of the peripheral, central, and autonomic nervous system function in styrene workers"],"prefix":"10.1002","volume":"20","author":[{"given":"Katsuyuki","family":"Murata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhito","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6166045"},{"key":"e_1_2_1_3_1","unstructured":"Antila K. (1979):Quantitative characterization of heart rate during exercise. Scand J Clin Lab Invest (suppl) 153 (Academic dissertation)."},{"key":"e_1_2_1_4_1","first-page":"427","article-title":"A case ofskin atrophy, neurogenic muscular atrophy and anxiety reaction following long exposure to styrene","volume":"13","author":"Araki S","year":"1971","journal-title":"Jpn J Ind Health"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1986.9935773"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700100207"},{"key":"e_1_2_1_7_1","first-page":"321","article-title":"Determination of the distribution of conduction velocities in workers exposedto lead, zinc, and copper","volume":"43","author":"Araki S","year":"1986","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_8_1","first-page":"341","article-title":"Determination of the distribution of nerve conduction velocities in chain saw operators","volume":"45","author":"Araki S","year":"1988","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_9_1","first-page":"826","article-title":"Impaired dopaminergic modulation of pituitary in workers occupationally exposed styrene: Further evidence from PRL response to TRH stimulation","volume":"29","author":"Arfini G","year":"1987","journal-title":"J Occup Med"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700080306"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.1979.326512"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000116046"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00377691"},{"key":"e_1_2_1_14_1","first-page":"234","article-title":"An investigation of the acute behavioural effect of styrene on factory workers","volume":"37","author":"Cherry N","year":"1980","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_15_1","first-page":"346","article-title":"Acute behavioural effects of styrene exposure: A further analysis","volume":"38","author":"Cherry N","year":"1981","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_16_1","first-page":"29","article-title":"Neurotoxic effects of styrene: Further evidence","volume":"47","author":"Cherry N","year":"1990","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_17_1","first-page":"301","article-title":"No acute behavioural effects of exposure to styrene: A safe level of exposure","volume":"42","author":"Edling C","year":"1985","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_18_1","first-page":"805","article-title":"Neuropsychiatric effects of low exposure to styrene","volume":"46","author":"Flodin U","year":"1989","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00381026"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2723"},{"key":"e_1_2_1_21_1","first-page":"412","article-title":"Autonomic neuropathy and vibration exposure in forestry workers","volume":"44","author":"Heinonen E","year":"1987","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00377941"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(77)90008-6"},{"key":"e_1_2_1_24_1","volume-title":"Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice.","author":"Kimura J","year":"1989"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(78)90086-5"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2811"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","unstructured":"Murata K Araki S. (1991): Autonomic nervous system dysfunction in workers exposed to lead zinc and copper in relation to peripheral nerve conduction: A study of R\u2010R interval variability.Am J Ind Med(in press).","DOI":"10.1002\/ajim.4700200509"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00377738"},{"key":"e_1_2_1_29_1","first-page":"245","article-title":"A role of cardiac para\u2010 and sympathetic function on heart rate variations","volume":"22","author":"Oikawa N","year":"1985","journal-title":"Auton Nerv Syst"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2721"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2748"},{"key":"e_1_2_1_32_1","first-page":"316","article-title":"Long\u2010term neurotoxicity of styrene: A quantitative study of glial fibrillaq acidic protein (GFA) and S\u2010100","volume":"46","author":"Rosengren LE","year":"1989","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_33_1","first-page":"113","volume-title":"Conduction Velocity Distributions. A Population Approach to Electrophysiology of Nerve.","author":"Sax DS","year":"1981"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2810"},{"key":"e_1_2_1_35_1","first-page":"113","volume-title":"Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System","author":"Shendan DF","year":"1988"},{"key":"e_1_2_1_36_1","article-title":"Effect of lead on cardiac parasympathetic function","volume":"63","author":"Teruya K","year":"1991","journal-title":"Int Arch Occup Environ Health"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00396601"},{"key":"e_1_2_1_38_1","first-page":"799","article-title":"Clinical and neurobehavioural study of the acute and chronic neurotoxicity of styrene","volume":"46","author":"Triebig G","year":"1989","journal-title":"Br J Ind Med"},{"key":"e_1_2_1_39_1","volume-title":"Styrene.","author":"World Health Organization","year":"1983"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130205"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880130406"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700200609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700200609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T06:20:45Z","timestamp":1698042045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700200609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1002\/ajim.4700200609"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700200609","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}