{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:21:41Z","timestamp":1774261301467,"version":"3.50.1"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,19]],"date-time":"2007-01-19T00:00:00Z","timestamp":1169164800000},"content-version":"vor","delay-in-days":5497,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Industrial Med"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After the outbreak of an epidemic of a strange disease characterized by severe neurological signs in the small Japanese town of Minamata, a number of scientists in different disciplines were required to identify the causal agent. An account is given of the three\u2010year program, with its disappointments and frustrations as a result of the limitations of knowledge of ecological principles and the absence of adequate techniques for detection and measurement. The lessons that have been learned on how toxic compounds can accumulate and concentrate in food chains are described as are the ecological contributions of environmentally safe waste disposal techniques. This article is based on the recollections of Dr. Shoji Kitamura, who contributed greatly to the discovery of the causative agent of Minamata disease.<\/jats:p>","DOI":"10.1002\/ajim.4700210215","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T12:28:23Z","timestamp":1176985703000},"page":"275-280","source":"Crossref","is-referenced-by-count":27,"title":["Historical perspectives in occupational medicine. The discovery of the causal agent of minamata disease"],"prefix":"10.1002","volume":"21","author":[{"given":"Kenzaburo","family":"Tsuchiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ie50334a024"},{"issue":"3","key":"e_1_2_1_3_1","first-page":"745","article-title":"Minamata\u2010byo ni Kansuru Dobutsu\u2010jikken\u2010seiseki (Dai 2 ho) (Animal Experiments data on Minamata Disease) (2nd. report) (in Japanese)","volume":"33","author":"Kitamura S","year":"1959","journal-title":"Kumamoto Igakkai Zassi"},{"issue":"12","key":"e_1_2_1_4_1","first-page":"847","article-title":"Minamata\u2010byo Kenkyu wo Kaerimite (Reflecting upon the study of Minamata disease), (in Japanese)","volume":"6","author":"Kitamura S","year":"1970","journal-title":"Summary FARUMASHIA"},{"key":"e_1_2_1_5_1","volume-title":"Eleven Blue Men and Other Narratives of Medical Detection","author":"Rouech\u00e9 B","year":"1947"},{"key":"e_1_2_1_6_1","volume-title":"Selenium\u2014Its Geological Occurrence and Its Biological Effects in Relation to Botany, Chemistry, Agriculture, Nutrition, and Medicine","author":"Trelease SF","year":"1949"}],"container-title":["American Journal of Industrial Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajim.4700210215","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajim.4700210215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:08:36Z","timestamp":1698124116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajim.4700210215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/ajim.4700210215"],"URL":"https:\/\/doi.org\/10.1002\/ajim.4700210215","archive":["Portico"],"relation":{},"ISSN":["0271-3586","1097-0274"],"issn-type":[{"value":"0271-3586","type":"print"},{"value":"1097-0274","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}